摘要
目的:研究补肾活血液预防和治疗地塞米松致雄性大鼠骨质疏松的效果,并探讨其作用机制。方法:采用12月龄SD雄性大鼠46只,随机分组给药,18周后分别测定全身骨密度(BMD)、股骨抗弯强度(FBS)以及血清中骨钙素(BGP)、甲状旁腺素(PTH)、睾酮(T)、雌二醇(E_2)的水平。结果:全身BMD、FBS预防组显著高于地塞米松组(P<0.01),与空白对照组比较未见明显差异;治疗组高于地塞米松组(P<0.05),但低于空白对照组(P<0.05);预防组、治疗组的血清T水平高于地塞米松组(P<0.01和P<0.05),血清PTH低于地塞米松组(P<0.05),血清E_2以及BGP的水平略高于地塞米松组,但无统计学意义。结论:补肾活血液可以有效地预防和治疗地塞米松诱导的雄性大鼠骨质疏松。
Objective:To study the efficacy of 'Bushen Huoxue Liquid' (BSHXL) in male rats with osteoporosis induced by dex-amethasone ( DM) and its mechanism. Methods:Forty-six male Sprague-Dawley rats at 18 months of age were chosen. They were divided into four groups, BSHXL and DM were administered appropriately for 12 weeks. General bone mineral density (GBMD) ,femur bending strength (FBS) ,serum-BGP,serum-PTH and serum-E2 were measured. Results:GBMD,FBS in BSHXL prevention group were significantly higher than those in DM group (P<0.01) , and the same with those in normal control group (P>0. 05). GBMD, FBS in BSHXL treatment group were higher than those in DM group (P<0.05) , and lower than those in normal control group. Compared with DM group, level of serum-T in BSHXL prevention group and BSHXL treatment group increased (P < 0. 05) and level of serum-PTH in those two groups decreased ( P < 0. 05). But in comparison with DM group, level of serum-E2 and serum-BGP in the above-mentioned two groups had no significant difference (P>0.05). Conclusion:BSHXL could prevent and treat osteoporosis in male rats induced by DM.
出处
《中药材》
CAS
CSCD
北大核心
2003年第5期347-349,共3页
Journal of Chinese Medicinal Materials
基金
广东省自然科学基金(No 990475)
广州市科技攻关计划(2002Z3-E5071)
中国博士后科学基金[1999]29号
广东省中医药局科研基金(No 99580
No 97248)
