摘要
目的探讨体重指数对体外受精-胚胎移植患者妊娠结局的影响。方法选择接受体外受精/卵泡浆内单精子注射-胚胎移植(IVF/ICSI-ET)治疗不孕病例共530例。根据体重指数(BMI)将纳入患者分为2组,A组360例,BMI<24 kg/m^2;B组170例,BMI≥24 kg/m^2。比较2组年龄、不孕年限、基础性激素、重组人促卵泡激素/注射用尿促卵泡素(Gn)总量、Gn刺激天数、注射人绒毛膜促性腺激素(HCG)日血清雌二醇(E2)水平、获卵数、全胚胎冷冻率、受精率、妊娠情况。结果 A组和B组年龄、不孕年限及基础促卵泡生成素(FSH)、基础促黄体生成素(LH)、基础E2及睾酮、垂体泌乳素比较,差异均无明显统计学意义(P>0.05)。A组Gn总量、Gn刺激天数均小于B组,差异有统计学意义(P<0.05);A组HCG日E2、获卵数、全胚胎冷冻率均大于B组(P<0.05)。2组正常受精率比较,差异无统计学意义(P>0.05)。A组和B组比较,着床率、生化妊娠率、临床妊娠率、自然流产率、活产率、早产率差异均无统计学意义(P>0.05)。结论高BMI女性在辅助助孕中表现为Gn刺激天数较长,Gn总量增加,获卵数偏少,HCG日E2水平偏低,但妊娠结局包括临床妊娠率、自然流产率、活产率及早产率无明显差别。
Objective To investigate the effect of body mass index(BMI)on pregnancy outcome of in vitro fertilization-embryo transfer(IVF-ET)patients.Methods 530 infertility cases were treated by in vitro fertilization/intracytoplasmic sperm injection-embryo transfer.According to BMI,the patients were divided into two groups:a total of 360 cases in group A(BMI<24 kg/m^2)and a total of 170 cases in group B(BMI≥24 kg/m^2).The age,duration of infertility,basic sex hormones,total Gn,days of Gn,E2 level of HCG day,number of eggs harvested,freezing rate of whole embryo,fertilization rate and pregnancy were compared between two groups.Results There were no significant differences in age,infertility years,basic FSH,basic LH,basic E2,testosterone and pituitary prolactin between group A and group B(P>0.05).The total amount of Gn and days of Gn in group A were less than those in group B(P<0.05);E2 level of HCG day,number of eggs harvested and rate of whole embryo freezing in group A were higher than those in group B(P<0.05).There was no significant difference in the normal fertilization rate between the two groups(P>0.05).There were no significant differences in implantation rate,biochemical pregnancy rate,clinical pregnancy rate,spontaneous abortion rate,live birth rate and premature delivery rate between group A and group B(P>0.05).Conclusion High BMI women probably have longer days of Gn stimulation,more Gn,fewer eggs and lower E2 level on HCG day.However,all parameters of pregnancy outcomes,including clinical pregnancy rate,abortion rate,live birth rate and premature delivery rate are comparable among two groups.
作者
刘丽
郝苗苗
张燕
包俊华
LIU Li;HAO Miaomiao;ZHANG Yan;BAO Junhua(Maternal and Children Health Hospital,Yinchuan 750001,China)
出处
《宁夏医学杂志》
CAS
2019年第9期807-809,共3页
Ningxia Medical Journal
基金
无创子宫内膜刺激改善子宫内膜容受性的临床研究(2018AAC03229)
关键词
肥胖
体重指数
体外受精/卵泡浆内单精子注射-胚胎移植
妊娠结局
Obesity
Body mass index
In vitro fertilization/intracytoplasmic sperm injection-embryo transfer
Pregnancy outcome
