摘要
开发了一种基于浮点编码遗传算法的模拟移动床色谱优化方法。该优化方法中将归一化的生产强度取最大值作为目标函数,同时将纯度的n次方作为罚函数。运算过程中浮点编码遗传算法的适度值由模拟移动床色谱的稳态模型求得。为了保证遗传算法每一代的个体均满足模拟移动床色谱本身的约束条件,算术杂交和完全非均匀变异被用作演化算子。采用该算法很容易得到模拟移动床色谱分离过程中非线性条件下的最优条件。这种优化算法被应用于木糖醇母液的模拟移动床色谱,结果表明当罚函数指数n值由小到大变化时,可以得到产品纯度由低到高的最优分离条件。进一步比较了当n值为20时的实验值与仿真值后发现,实验结果与仿真值相吻合,木糖和木糖醇的纯度分别达到99 51%和99 26%。
An effective strategy based on real coded genetic algorithms was developed to optimize the operating conditions of simulated moving bed chromatography. The optimization algorithm's objection function was the normalized production intensity. In addition, the n exponent of purity was used as penalty function. The fitness of real coded genetic algorithm fitness was calculated with steady model of simulated moving bed chromatography. In order to satisfy the constrain conditions of simulated moving bed chromatography, the arithmetic crossover and completelynon uniform mutation were used as the operators of the real coded genetic algorithm. The parameters of real coded genetic algorithm were population size 60, probability of crossover 40%, probability of mutation 10%, and generation 1?000, respectively. With this algorithm, it was easy to find the optimization condition of simulated moving bed chromatography separating progress under nonlinear condition. Then, this optimization algorithm was used to optimize the separation condition of mother liquid of xylitol with simulated moving bed chromatography. It was found that the optimized separation conditions of different purity products could be gotten by changing the value of penalty function coefficient n. When n value changed from 5 to 80, the purity of products changed from 9465% to 9986% with optimized operating conditions. And the computer emulated results and the experimental results were compared when the n value equals to 20. The results showed that they were coincident. The purities of xylitol and xylose from experimental results were 9951% and 9926%, respectively.
出处
《色谱》
CAS
CSCD
北大核心
2003年第3期206-209,共4页
Chinese Journal of Chromatography
关键词
浮点编码
遗传算法
优化
模拟
移动床
色谱分离
木糖醇母液
生产
genetic algorithm
real coded
optimization
simulated moving bed chromatography
mother liquid of xylitol
