摘要
目的 :探讨应用大剂量静脉免疫球蛋白在新生儿ABO溶血病治疗中的作用和临床效果。方法 :将 36例新生儿ABO溶血病患儿随机分为免疫球蛋白治疗组 (1 9例 )和对照组 (1 7例 ) ,两组在给予综合退黄治疗的基础上 ,免疫球蛋白治疗组加用单次大剂量静脉免疫球蛋白静脉滴注 ,并动态观察两组血清总胆红素、间接胆红素、血红蛋白水平和光疗时间。结果 :与对照组相比 ,入院后 2 4、48、72h免疫球蛋白治疗组血清总胆红素水平明显降低 ,血红蛋白水平逐渐升高 ,光疗时间缩短 ,两组有显著性差异 (P均 <0 .0 5或 <0 .0 1 )。免疫球蛋白治疗组无一例换血 ,对照组有 3例需要换血治疗。结论 :早期及时应用大剂量静脉免疫球蛋白治疗新生儿ABO溶血病 ,能阻断溶血的继续发生 ,快速降低患儿的血清总胆红素水平 ,防止血红蛋白进一步下降 ,避免换血治疗 。
Objectives To study the action and the clinical effects of high-dose intravenous immune globulin therapy for neonatal ABO hemolytic disease. Methods A total of 36 neonates with ABO hemolytic disease were divided into immune globulin treated group ( n =19) and control group ( n =17) randomly. The compositive treatment were administered to all cases and the high-dose intravenous immune globulin were only once used in immune globulin treated group in addition. The levels of serum total bilirubin, indirect bilirubin, hemoprotein and the hours of phototherapy were observed continuously. Results It showed that the levels of serum total bilirubin decreased significantly, while the concentration of hemopretein increased remarkably (all P <0.05 or 0.01) and the hours of phototherapy were shortened greatly ( P <0.05) in immune globulin treated group compared with the time in control group at 24, 48, 72 hours after hosptolization. There were 4 cases of exchange transfusion in control group and no case in immune globulin-treated group. Conclusion Using high-dose intravenous immune globulin in time is an effective method of therapy for neonatal ABO hemolytic disease because it can stop hemolysis from continuous ocurrence;it reduces quickly the levels of serum total bilirubin, prevent thes concentration of hemopretein from descending further and avoid using the therapeutics of exchange transfusion.
出处
《郧阳医学院学报》
2003年第1期25-27,共3页
Journal of Yunyang Medical College
