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阿尔茨海默病中tau蛋白和铝的变化及二者的关系 被引量:3

Changes and relationship of protein tau and Aluminum in Alzheimer`s disease
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摘要 目的 了解tau蛋白和铝在阿尔茨海默病发生中的研究状况和相互关系。方法 查阅近 2 0年国内外相关文献。结果 铝水平升高和tau蛋白分子结构与功能改变具有重要关系 ,并都参与了阿尔茨海默病的发生。结论 降低脑铝含量。
出处 《新乡医学院学报》 CAS 2003年第3期189-192,共4页 Journal of Xinxiang Medical University
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参考文献18

  • 1王建枝,龚成新.蛋白磷酸酯酶对Alzheimer神经原纤维缠结的松解作用[J].中国生物化学与分子生物学报,1999,15(1):123-127. 被引量:5
  • 2Chambers CB, Lee JM, Troncoso JC, et al . Overexpression of four - repeat tau mRNA isforms in progressive supranuclear palsy but not in Alzheimer' s disease[ J ]. Annals Neuro , 1999,46(3) :325 - 332.
  • 3Strong M.J, Mao K, Nerurkar Vr, et al . Dose- dependent selective supression of light (NFL) and medium (NFM) but not heavy (NFH)molecular weight neurofilament mRNA levels in acute aluminum neurotoxocity[J ]. Mol Cell Neurosci ,1994,5(4):319-326.
  • 4Kopke E,Tung YC,Shaikh S, et al. Microtubule- associated protein tau :abnormal phosphorylation of a non - paired helical filament pool in Alzheimer disease[ J ]. J Bio Chem , 1993,268:24374 - 24384.
  • 5Arendt T, Holzer M ,Grobmann A, et al . Increased expression and subcellular translocation of mitogen activated protein kinase kinase and mitogen activated protein kinase in Alzheimer disease[J ]. Neuroscience , 1995,68( 1 ):5 - 18.
  • 6Masahiro Y, Emmanuel P, Koichi I, et al . Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer' s disease[ J ].FEBS Lett , 1999,461:329 - 333.
  • 7Qingyi Z,Jack B,Eva- Maria M, et al . Sequential phosphorylation of tau by glycogen synthese kinase- 3b and protein kinase A at Thr212 and Ser214 generates the Alzheimer- specific epitope of antibody AT100 and requires a paired- helical- filament- like conformation[ J ]. FEBS ,1998,252:542- 552.
  • 8Ko LW, Ko EC, Nacharaju P, et al . An immunochemical study on tau glycation in paired helical filaments[J]. Brain Res , 1999,830(2) :301-313.
  • 9Durany N, Munch G, Michel T, et al . Investigations on oxidative stress and therapeutical implications in dementia[J ]. Eur Arch Psychiatry Clin Neurosci , 1999,249 Suppl 3 : 68 - 73.
  • 10Van- Landeghem GF,Sikstrom C,Beekman LE, et al . Transferrin C2,metal binding and Alzheimer's disease[J]. Neuroreport , 1998,9(2):177- 179.

二级参考文献4

  • 1Wang J Z,Brain Res,1996年,38卷,200页
  • 2Wang J Z,Nature Med,1996年,2卷,871页
  • 3Wang J Z,J Biol Chem,1995年,270卷,4854页
  • 4Iqbal K,Research Advances in Alzheimer Disease and Related Disorders,1995年,513页

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