摘要
目的 研究乙肝高价免疫球蛋白 (HBIg)阻断乙肝表面抗原 (HSsAg)阳性孕妇乙型母婴传播效果。方法 79例HBsAg阳性孕妇随机分为治疗组 (n =44 )和对照组 (n =3 5 ) ,均在妊娠 2 8周时抽取静脉血检测HBsAg、HBeAg和HBVDNA。治疗组自 2 8周开始每 4周肌注一次HBIg ( 2 0 0IU)直至分娩。对照组不给予上述药物。新生儿出生后即抽取脐静脉血检测HBVDNA。结果 治疗组新生儿HBVDNA阳性率明显低于对照组。HBeAg阳性孕妇所生新生儿HBVDNA阳性率明显高于HBeAg阴性者。结论 HBIg能有效降低HBsAg阳性孕妇的宫内感染率 ,HBVDNA检测可以作为是否应用HBIg的指征。
Objective To study the immunoglobulin of Hepatitis B in Stopping transmission of Hepatitis B from mother to infant. Methods 79 cases of HBsAg positive gravida were divided into treatment group(n=44) and control group(n=35) randomly, and HBsAg , HBeAg and HBVDNA of venous blood were detected at the 28 th week of pregnancy. HBIg (200IU) was injected into muscles for the treatment group every 4 weeks since that time until delivery, and the control group nothing. HBVDNA of umbilical cord blood of the newborn was detected right after the delivery. Results The positive rate of HBVDNA of the treatment group was lower than the control group. The HBVDNA of the newborn of the HBeAg positive gravida was higher than the HBeAg negative gravida . Conclusion HBIg could effectively decrease the intrauterine infection rate of HBsAg gravida, and the detection of HBVDNA could be used as an index for the application of HBIg.
出处
《浙江预防医学》
2003年第7期10-11,共2页
Zhejiang Journal of Preventive Medicine
