摘要
目的:研究纤维蛋白原(FIB)、纤溶酶原激活剂抑制物-1(PAI-1)、血管假性血友病因子(vonWillebrand因子,vWF)、血栓素A2(TXA2)、前列腺环素(PGI2)等促凝因子在急性冠脉综合征(ACS)患者预后中的作用。方法:连续观察76例ACS患者入院时上述指标的变化,随访3～7个月,记录住院期间和出院后新发生的心血管事件。结果:ACS患者血浆中FIB、PAI-1、vWF、TXB2浓度明显高于正常对照。随访期内发生心血管事件者FIB和vWF浓度高于未发生者;多因素logistic回归分析显示FIB和vWF是心血管事件的独立危险因素。结论:FIB、PAI-1、vWF、TXA2参与ACS发病机制。FIB和vWF影响ACS患者短期预后。
Objective:To study the predictive value in cardiac events of ACS patients of thrombogenic mediators such as fibrinogen,plasminogen activator inhibitor type-1(PAI-1),von Willebrand factor(vWF),thromboxane A 2 (TXA 2 )and prostacycline(PGI 2 ).Methods:Continuously observed76cases of ACS patients,and followed for3～7months.Results:Concentrations of fibrinogen,PAI-1,vWF and TXB 2 were significantly raised compared with the normal controls.Those who developed cardiac events had higher fibrinogen and vWF levels than those who survived free.Multivariate logistic regression analysis demonstrated fibrinogen and vWF were independent risk factors.Conclusions:Fibrinogen,PAI-1,vWF and TXA 2 played roles in the pathogenesis of ACS.Fibrinogen and vWF had influence on the prognosis of ACS patients in short follow-up period.
出处
《山东大学学报（医学版）》
CAS
2003年第3期271-274,共4页
Journal of Shandong University:Health Sciences
关键词
急性冠脉综合征
促凝因子
预后
Acute coronary syndrome
Thrombogenic mediator
Prognosis
