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应用cDNA微阵列技术研究MMP1,TIMP1基因在肺癌中的表达 被引量：1

Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique
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摘要 研究基质金属蛋白酶 1 (MMP1 )和基质金属蛋白酶组织抑制物 1 (TIMP1 )基因在肺鳞癌、肺腺癌中的表达。方法 :利用含 4 0 96个基因的cDNA微阵列检测肺鳞癌、肺腺癌组织与正常肺组织的差异表达基因 ,重点分析MMP1 ,TIMP1在肺鳞癌与肺腺癌中的表达。结果 :MMP1 ,TIMP1基因在肺鳞癌与肺腺癌中均表达上调。结论 :MMP1 ,TIMP1在肺鳞癌、肺腺癌中均出现表达上调 ,可作为肺鳞癌。 Objective To investigate the gene expression of matrix metalloproteinases 1( MMP 1) and tissue inhibitors of matrix metalloprotainases 1( TIMP 1) in squmas cell lung cancer and adenocarcinoma .Methods Gene expression profile cDNA microarray cgntaining 4 096 genes was used to identify differentially expressed genes in squmas cell lung cancer and adenocarcinoma,and to analyze the gene expression of MMP1 and TIMP 1.Results Gene MMP1 and TIMP 1 were differentially expressed in both squmas cell lung cancer and adenocarcinoma,and both of them were up regulated. Conclusion MMP 1 and TIMP 1 may be important molecular markers of squmas cell lung cancer and adenocarcinoma.
作者 欧阳取长 胡成平 梁清华 石林阶 吴鄂生 杨红忠 潘频华
机构地区 中南大学湘雅医院呼吸科 中南大学湘雅医院中西医结合研究所
出处 《湖南医科大学学报》 CSCD 北大核心 2003年第3期227-228,共2页 Bulletin of Hunan Medical University
关键词 应用 cDNA微阵列技术 研究 MMP1 TIMP1基因 肺癌 表达 gene expression matrix metalloproteinases 1 tissue inhibitors of matrix metalloprotainases 1 cDNA microarrays
分类号 R734.2 [医药卫生—肿瘤]
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参考文献8

  • 1FongKⅢ Kida Y Zimmerman PV.TIMP1 and adverse prognosis in non-small cell lung cancer[J].Clin Cancer Res,1996,2:1369-1372.
  • 2Schutz A, Schneidenbach D, Aust G, et al. Differential expression and activity status of MMP1 ,MMP2 and MMP9 in tumor and stroreal cells of squmas cell carcinomas of the lung [ J ]. Tumor Biol,2002,23 : 179 -184.
  • 3Zhu Y,Spitz MR,Lei L,et al. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility[ J ]. Cancer Res,2001,61:7825-7829.
  • 4Fong K III, Kida Y, Zimmerman PV. TIMP1 and adverse prognosis in non-small cell lung cancer [ J]. Clin Cancer Res, 1996,2:1369-1372.
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同被引文献5

  • 1Seiki M. Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion[J]. Cancer Lett, 2003,194(1): 1～11.
  • 2Sugioka Y, Watanabe T, Inagaki Y, et al. C-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line[J]. Int J Cancer,2004,109(6): 867～874.
  • 3Brummer O, Bohmer G, Hollwitz B,et al. MMP-1 and MMP-2 in the cervix uteri in different steps of malignant transformation--an immunohistochemical study[J]. Gynecol Oncol,2002,84(2):222～227.
  • 4Bendardaf R, Lamlum H, Vihinen P, et al. Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma[J]. Oncology,2003,65(4):337～346.
  • 5Schutz A, Schneidenbach D, Aust G, et al. Differential expression and activity status of MMP-1, MMP-2 and MMP-9 in tumor and stromal cells of squamous cell carcinomas of the lung[J]. Tumour Biol, 2002 ,23(3): 179～184.

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湖南医科大学学报
2003年 第3期

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