摘要
维生素K与骨质疏松关系密切,可通过酶的机制影响谷氨酸γ-羧基化骨钙素的合成和分泌,促进骨形成,抑制骨吸收,提高骨量。此外,维生素K还可能通过影响肾钙素及IL-1、IL-6,调节钙平衡,间接影响骨代谢。大量流行病学研究及临床干预试验证实,维生素K不仅可以增加骨质疏松患者骨密度,而且可以降低其骨折发生率,促进骨健康。但维生素K应用于临床防治骨质疏松症尚需进一步探讨,目前美国医学会将饮食中维生素K摄入量参考值标准提高了50%,即19岁以后女性为90μg/d,男性为120μg/d。
There is a closely relationship between vitamin K and osteoporosis.As a cofactor for carboxylase activity,vitamin K can facilitate the conversion of glutamyl to gamma -carboxyglutamyl residues and influence the synthesis and excretion of gamma -carboxylation of osteocalcin to increase the formation of bone.Vitamin K can also effectively inhibit the absorption of bone mass.Besides,there are increasing evidences that vitamin K can effect the synthesis and excretion of nephrocalcin and interlukin-1,6that can regulate calcium balance and bone metabolism.Meanwhile,there is a consistent line of evidence in human epidemiologic and intervention studies that clearly demonstrate that vitamin K can not only increase bone mineral density in osteoporotic people,but also reduce fracture rates to improve bony health.However more researches are required before vitamin K is widely applied in prevention and treatment of osteoporosis.The American Medical Association recently has increased the dietary reference intakes of vitamin K to90mg /d for females and120mg /d for males.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2003年第3期346-349,共4页
Acta Academiae Medicinae Sinicae
