摘要
目的观察HBe Ag阴性慢性乙型肝炎患者核苷(酸)类似物(NUCs)停药后病情复发情况,分析相关因素。方法选择2011年6月—2015年6月在太仓市第一人民医院和苏州市第五人民医院住院及门诊服用NUCs停药后复发的HBe Ag阴性慢性乙型肝炎患者39例,分为规范停药后复发组(A组)16例和不规范停药后复发组(B组)23例。另外选择同期服用NUCs停药后1年内未复发的HBe Ag阴性慢性乙型肝炎患者9例作为未复发组。分析停药后1年内肝炎复发情况和相关因素。结果未复发组患者基线血清HBV DNA低于A、B组,差异有统计学意义(P<0.05),A组基线血清HBV DNA与B组比较,差异无统计学意义(P>0.05);未复发组患者基线血清HBs Ag水平低于B组,差异有统计学意义(P<0.05),但与A组比较,差异无统计学意义(P>0.05);未复发组患者停药时血清HBs Ag水平低于A、B组,差异有统计学意义(P<0.05),A组停药时血清HBs Ag水平与B组比较,差异无统计学意义(P>0.05)。结论 HBe Ag阴性慢性乙型肝炎患者服用NUCs规范停药或不规范停药后1年内均有复发,不规范停药后6个月以内复发率较高,患者基线血清HBV DNA水平、基线血清HBs Ag或停药时血清HBs Ag水平与复发可能有关。
Objective To analyze the relapse and related factors of the HBe Ag negative chronic hepatitis B after nucleos( t) ide analogues( NUCs) drug withdrawal. Methods A total of 39 patients with HBe Ag negative chronic hepatitis B after NUCs drug withdrawal in the First People’ s Hospital of Taicang City and the Fifth People’ s Hospital of Suzhou City from June 2011 to June 2015 were selected,they were divided into A group( with relapse after standard drug discontinuance,n =16) and B group( with relapse after non standard drug discontinuance,n = 23). A total of 9 patients with HBe Ag negative chronic hepatitis B treated by NUCs( without relapse within 1 year of drug discontinuance) were selected as C group at the same time. The incidence of relapse and related factors were analyzed. Results Baseline serum HBV DNA of C group was lower than A,B group( P < 0. 05),baseline serum HBV DNA between A group and B group showed no significant differences( P >0. 05); baseline serum HBs Ag of C group was lower than B group( P < 0. 05),but compared with A group,the differences were not statistically significant( P > 0. 05); serum HBs Ag of C group was lower than the A,B group( P < 0. 05),serum HBs Ag between A group and B group showed no significant differences( P > 0. 05). Conclusion HBe Ag negative chronic hepatitis B patients taking NUCs with standard drug discontinuance or not appear relapse within 1 year,patients with non- standard drug has high recurrence rate within the six months baseline serum HBV DNA,baseline serum HBs Ag or discontinuation of serum HBs Ag levels maybe associated with recurrence.
出处
《临床合理用药杂志》
2016年第9期10-12,共3页
Chinese Journal of Clinical Rational Drug Use
