摘要
目的探讨单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效。方法选取福州儿童医院2015年2月—2016年3月收治的新生儿缺氧缺血性脑病患儿96例,按照随机数字表法分为对照组和观察组,各48例。两组患者均采用常规治疗方法,对照组给予胞二磷胆碱治疗,观察组给予单唾液酸四己糖神经节苷脂治疗,比较两组患儿的临床疗效、新生儿神经行为测定法(NBNA)评分以及症状改善时间。结果观察组治疗总有效率高于对照组(P<0.05)。且观察组患儿治疗后3、7、14d NBNA评分均高于对照组,意识恢复时间、吸吮能力恢复时间、肌张力恢复时间及原始反射恢复时间均短于对照组(P<0.05)。结论单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病临床疗效明显,可有效缩短症状改善时间。
Objective To discuss the clinical effect of monosialotetrahexosylganglioside in treating hypoxic ischemic encephalopathy. Methods A total of 96 children with hypoxic ischemic encephalopathy were selected from February 2015 to March 2016 in the Fuzhou Children’s Hospital,which were randomly divided into control group and observation group,48 cases in each group. Two groups were all given conventional therapy,the control group was treated with citicoline,the observation group was treated with monosialotetrahexosylganglioside,the clinical effect,NBNA scores and improvement time of symptoms were compared between two groups. Results The total treatment effective rate of observation group was higher than control group( P < 0. 05). After 3 days,7 days and 14 days of treatment,the NBNA scores of observation group were higher than control group,the recovery time of consciousness,sucking activity,muscular tension and primitive reflex of observation group were shorter than control group( P < 0. 05). Conclusion Monosialotetrahexosylganglioside has an obvious clinical effect in treating hypoxic ischemic encephalopathy,can effectively shorten the improvement time of symptoms.
出处
《临床合理用药杂志》
2016年第18期27-28,共2页
Chinese Journal of Clinical Rational Drug Use
