摘要
目的观察来氟米特联合泼尼松治疗难治性肾病综合征的临床效果。方法将60例难治性肾病综合征患者随机分为观察组与对照组各30例,观察组给予来氟米特联合泼尼松治疗,对照组给予环磷酰胺联合泼尼松治疗,比较2组的疗效及治疗前后24h尿蛋白定量、尿素氮、血肌酐的变化情况。结果观察组总有效率96.7%,对照组总有效率90.0%,2组疗效比较差异无统计学意义(P>0.05)。治疗前2组24h尿蛋白、尿素氮、血肌酐比较差异无统计学意义(P>0.05);治疗后2组患者的24h尿蛋白、尿素氮、血肌酐与治疗前比较均明显降低,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为26.7%低于对照组的43.3%,但差异无统计学意义(P>0.05),2组患者耐受性均较好,无患者因不良反应而退出研究。结论来氟米特联合泼尼松治疗难治性肾病综合征疗效好,能改善患者的肾功能,值得推广和应用。
Objective To observe effect of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome. Methods 60 patients with refractory nephrotic syndrome were randomly divided into observation group and control group,each with 30 patients. The observation group was treated with leflunomide combined with prednisone,and control group was treated with cyclophosphamide combined with prednisone. Clinical curative effect,and the changes of 24 hours urine protein,blood urea nitrogen and serum creatinine between the two groups were compared. Results The total effective rate of observation group was 96. 7%,and total effective rate of control group was 90. 0%,the difference was not statistically significant( P > 0. 05). Before the treatment,the difference of 24 hours urine protein,urea nitrogen,serum creatinine between the two groups were not statistically significant( P > 0. 05); After the treatment,24 hours urinary protein,blood urea nitrogen and serum creatinine of the two groups were both significantly decreased than before,and those indexes of observation group were lower than control group,the differences were statistically significant( P < 0. 05). The incidence of adverse reactions of the observation group( 26. 7%) was lower than that of control group( 43. 3%),but the difference was not statistically significant( P >0. 05). The patients of the two groups were well tolerated,and no patient withdrew from the study because of adverse reactions.Conclusion Leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome has good curative effect,and can improve the renal function of patients,which is worthy of promotion and application.
出处
《临床合理用药杂志》
2016年第31期22-23,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
难治性肾病综合征
来氟米特
泼尼松
环磷酰胺
Refractory nephrotic syndrome
Leflunomide
Prednisone
Cyclophosphamide
