摘要
目的观察含奥沙利铂方案经皮肝动脉化疗栓塞术(TACE)治疗肝癌的临床疗效和不良反应。方法对68例肝癌患者进行含奥沙利铂方案的TACE治疗,每例完成2~3次后评价疗效及不良反应。结果 68例中完全缓解(CR)8例(11.8%),部分缓解(PR)55例(80.9%),稳定(SD)2例(2.9%),进展(PD)3例(4.4%),总有效率为92.6%(63/68)。甲胎蛋白下降幅度为86.7%(52/60)。主要不良反应为胃肠道反应及白细胞减少。结论含奥沙利铂方案TACE治疗肝癌的疗效较好,临床症状显著改善,不良反应轻。
Objective To observe clinical efficacy and adverse reactions of oxaliplatin containing regimen in the percutaneous transcatheter arterial chemoembolization(TACE) in the treatment of hepatocellular carcinoma. Methods 68 advanced hepatocellular carcinoma patients were treated with oxaliplatin-containing regimen in the TACE. The clinical efficacy and adverse reactions were studied after 2 ~ 3 times treatment. Results Among them,8 cases(11. 8%) were in complete response(CR); 55 cases(80. 9%) were in partial response(PR); 2 cases(2. 9%) were stable(SD); 3 cases(4. 4%) were in progress(PD); Total efficiency rate was 92. 6%(63/68). The rate of descent of Alpha fetal protein was 86. 7%(52/60). The major side effects were digestive tract side effect and leukopenia. Conclusion Oxaliplatin-containing regimen in the TACE of advanced hepatocel lular carcinoma patients is an efficient method with few side effects.
出处
《临床合理用药杂志》
2016年第34期16-16,18,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
肝癌
奥沙利铂
经皮肝动脉化疗栓塞术
Hepatocellular carcinoma
Oxaliplatin
Transcatheter arterial chemoembolization
