摘要
目的探讨甲氨蝶呤联合米非司酮先期干预治疗内生型剖宫产瘢痕部位妊娠(CSP)的临床疗效。方法选取双流第一人民医院2016—2018年收治的内生型CSP患者104例,采用随机数字表法分为对照组和观察组,各52例。对照组患者行宫腔镜下吸刮术治疗,观察组患者采取甲氨蝶呤联合米非司酮先期干预,血人绒毛膜促性腺激素(β-HCG)水平下降≥25%后行宫腔镜下吸刮术治疗。比较两组患者术中与术后出血量、血β-HCG下降至正常水平时间、住院时间、治疗成功率,并观察两组患者不良反应与并发症发生情况。结果观察组患者术中与术后出血量少于对照组,血β-HCG下降至正常水平时间短于对照组,住院时间长于对照组,治疗成功率高于对照组(P<0.05)。两组患者均未出现严重不良反应和并发症。结论甲氨蝶呤联合米非司酮先期干预治疗CSP的临床疗效确切,可改善患者临床症状及体征,且安全性较高。
Objective To investigate the clinical efficacy of methotrexate combined with mifepristone early intervention for endogenous CSP.Methods A total of 104 endogenous CSP patients were selected from 2016 to 2018 in Shuangliu First People’s Hospital,which were randomly divided into control group and observation group according to random number table,52 cases in each group.The control group was treated with hysteroscopic aspiration and curettage,while the observation group was treated with methotrexate combined with mifepristone prior intervention.The level of bloodβ-HCG decreased by more than 25%before hysteroscopic aspiration and curettage.The amount of bleeding during and after operation,the time of bloodβ-HCG descending to normal level,hospitalization time,the success rate of treatment,adverse reactions and complications during after treatment were compared between the two groups.Results The observation group of amount of bleeding during and after operation was less than the control group,the time of bloodβ-HCG descending to normal level was shorter than the control group,the hospitalization time was longer than the control group,and the success rate of treatment was higher than the control group(P<0.05).There were no serious adverse reactions and complications in both groups.Conclusion Methotrexate combined with mifepristone early intervention for endogenous cesarean scar pregnancy has definite clinical effect,it can improve clinical symptoms and signs,and with high safety.
作者
曾凡英
刘娟
ZENG Fan-ying;LIU Juan(Department of Obstetrics and Gynecology,Shuangliu First People's Hospital,Chengdu 610200,China;不详)
出处
《临床合理用药杂志》
2019年第24期43-44,46,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
剖宫产术
瘢痕
妊娠
内生型
甲氨蝶呤
米非司酮
Cesarean section
Cicatrix
Pregnancy
Endogenetic type
Methotrexate
Mifepristone
