摘要
目的研究更昔洛韦凝胶剂的制备及其基本性质。方法以卡波姆940为凝胶基质,采用增溶与助溶手段,紫外分析法与高效液相色谱法。结果紫外扫描显示,更昔洛韦原料在254.2 nm处有最大吸收;HPLC测定显示,在3.842~15.296 mg·L-1内药物质量浓度与峰面积线性关系良好(ρ=1×10-5A+0.455 6,r2=0.999 9);所制备的更昔洛韦凝胶剂在高热、低温及离心条件下稳定性良好。结论更昔洛韦凝胶剂制备工艺简单,性质稳定,质量控制方法可行。
Objective To study the preparation and basic properties of GCV gel.Methods Carbopol 940 was used as the gel matrix,and the GCV gel was prepared by means of solubilization and cosolvent.UV spectrometry and HPLC methods were applied to study the basic properties of GCV gel.Results UV scanning indicated that GCV's max absorption was at254.2 nm.HPLC method,used to detect GCV concentration,had a great linearity between drug concentration and the area of peak(ρ=1×10-5A+0.455 6,r2=0.999 9).The GCV gel was stable at high or low temperature,and stable under centrifugation.Conclusions The preparation of GCV gel is simple,and prepared preparation is stable and quality controllable.
出处
《中国药剂学杂志（网络版）》
2004年第6期127-131,共5页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
凝胶剂
增溶
更昔洛韦
卡波姆
基本性质
制备
pharmaceutics
gel
solubilization
ganciclovir
carbopol
properties
preparation
