摘要
目的 考察多索茶碱和莫西沙星在大鼠体内的药动学特性及合用时的相互作用。方法 采用高效液相色谱法测定大鼠给药后不同时间的多索茶碱和莫西沙星的血浆浓度。血浆浓度 时间数据用非线性程序WINNONLIN拟合 ,求得药动学参数。结果 两药合用与单独用药时的药 时曲线基本一致 ,多索茶碱呈一级吸收一级开放式模型 ,莫西沙星呈一级吸收二室开放式模型 ,药动学参数无统计学差异。但多索茶碱与莫西沙星合用时 ,多索茶碱的代谢产物之一茶碱的AUC约是单用多索茶碱时的 2倍。结论 两药合用药动学上无明显的相互作用 ,但莫西沙星有减慢多索茶碱的代谢产物茶碱代谢的趋势 ,两药可以同时服用 。
OBJECTIVE: To study the pharmacokinetic interaction after oral administration of doxofylline and moxifloxacin in rats. METHODS: After oral administration of doxofylline and moxifloxacin, the drug levels in plasma were measured by HPLC. The plasma concentration-time data were accessed by non-linear program (WINNOLIN) and the pharmacokinetic parameters were obtained. The interaction of the pharmacokinetics between doxofylline and moxifloxacine were evaluated by student-t test. RESULTS: No significant difference was found on the pharmacokinetic parameters of doxofylline and moxifloxacine before and after co-administration. But the AUC of doxofylline's metabolite theophylline after co-administration was two times higher than single administration. CONCLUSION: There was no obvious interaction of pharmacokinetics when doxofylline and moxifloxacin were co-administered. They can be taken simultaneously, but the concentration of theophylline in plasma should be monitored.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2003年第4期285-289,共5页
Chinese Pharmaceutical Journal
关键词
多索茶碱
莫西沙星
大鼠
体内
药动学
相互作用
Drug interactions
High performance liquid chromatography
Metabolites
