摘要
对婷美减肥美容胶囊进行了毒理学安全性评价。结果:急性经口LD_(50)为10 g/kg,Ames试验、骨髓细胞微核试验和小鼠精子畸变试验均为阴性,30 d喂养试验4.50 g/kg组(相当于人群推荐量0.045 g/kg的100倍)雄鼠体质量增长缓慢,增加质量、饲料摄入量、食物利用率及游离脂肪酸均明显低于阴性对照组,平均每日排便量、胃、睾丸的脏体比明显高于阴性对照组,未发现对血液学指标、生化指标、肝肾功能,蛋白、脂肪、糖的代谢有明显影响。表明受试物除影响体质量增长外,无其他有害影响。
The authors have studied the toxicological safety of Tingmei diet cosmetology capsule. The median lethal dose LD50 in mice was 10 g/kg. Ames test, bone marrow cell micronucleus test and the mice sperm abnormality test in mice were negative. In the 30 day toxicity feeding study, the body weight of male mice in 4.50 g/kg body weight (the dosage was 100 times more than that for people, the dosage for people is 0.045 g/kg) group increased slowly. Weight gain, forage ingestion, food utilization rate and nonesterified fatty acid (NEFA) were obviously lower than those of the negative control group, then the daily defecation and visceral-body rate of stomach and spermary were obviously higher than those of the negative control group. It was not yet found that Tingmei diet cosmetology capsule obviously affected haematological system, function of liver and kidney, metabolizability of protein, fat or glucose. The result indicates that Tingmei capsules have not harmful effect except affecting weight gain.
出处
《首都医科大学学报》
CAS
2003年第2期124-128,共5页
Journal of Capital Medical University
