摘要
目的:探讨全麻药对小鼠周围运动神经和感觉神经的影响。方法:将50只小鼠分为5组,分别是用α-氯醛糖、戊巴比妥钠、氨基甲酸乙酯、水合氯醛、氯胺酮进行腹腔麻醉后,测定坐骨神经感觉神经动作电位(SNAP)和腓肠肌复合肌肉动作电位(CMAP),并比较其潜伏期、波幅、传导速度。结果:氯胺酮组的SNAP和CMAP的传导速度都最快,而α-氯醛糖组的SNAP的潜伏期、波幅、传导速度都最差。结论:在实验性研究或临床应用周围神经电生理检测时,选用氯胺酮或戊巴比妥钠麻醉较为理想。
Objectives: To explore the effect of the various anesthetic drugs on the funtion of peripheral
sensory and motor nerves in mouse. Methods: 50 mice were divided into 5 groups and each group was injected with different anesthetic drug (α - chloralose, pentobarbital, urethane, chloral hydrate and ketamine) . After anesthesia, their sensory nerve action potential (SNAP) of sciatic nerves and compound muscle action potential ( CMAP) of gastrocnemius muscles were detected by an electrophysiological recorder. Results: The ketamine had the quickest conductive velocity of the SNAP and the CMAP in the five anesthetic drugs: while the α - chloralose had the lowest conductive velocity of the SNAP and the CMAP in the five anesthetic druge. Conclusion: The ketamine is a better anesthetic drug in investigating and determining the function of peripheral nerves.
出处
《现代电生理学杂志》
2003年第2期78-80,共3页
Journal of Modern Electrophysiology
