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FDG肿瘤显像相关分子机制研究进展 被引量：3

Progression of molecular mechanisms of tumor ^(18)F-FDG PET imaging
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摘要 18F-FDG(18F-氟代脱氧葡萄糖)PET显像是依靠不同组织对18F-FDG的吸收差异来完成的,18F-FDG在肿瘤中的摄取增高与肿瘤的代谢及增殖情况、病理分级、分化程度、细胞的增生活性、倍增时间等生物学特性密切相关。进一步研究FDG吸收机制,将有助于对肿瘤的生物学特性更深一步的了解。 F-FDG( 18 F-fluorodeoxyglucose)PET imaging depends on different uptake of 18 F-FDG in different tissues.The uptake of 18 F-FDG in tumor tissue correlates with tumor's biologic behavours,such as metabolism,proliferating,pathologic stage,differentiation,the proliferating acitivity of cells and double times.With more knowlegement of the mechanisms of 18 F-FDG uptake,we'll know more about tumour's biologic behavours.
作者 李金丽 邢力刚 于金明 林祥通
机构地区 山东省肿瘤医院放疗科(济南 天津医科大学(天津 山东省肿瘤医院放疗科 复旦大学附属华山医院核医学科
出处 《国外医学（放射医学核医学分册）》 2003年第3期111-114,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 肿瘤 ^18F-氟代脱氧葡萄糖 核素显像 分子机制 研究进展 生物学特性 mechanisms deoxyglucose positron emission tomography
分类号 R730.4 [医药卫生—肿瘤]
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参考文献18

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同被引文献27

  • 1汪涛,孙玉鹗,姚树林,田嘉禾,刘小兵,王昆.肺腺癌葡萄糖易化扩散转运蛋白-1过度表达与^(18)氟脱氧葡萄糖摄取的关系[J].中华外科杂志,2004,42(16):968-971. 被引量：3
  • 2陈敏,郭佑民,郭晓娟,张少娟,杨健,金晨望.应用FDG-PET对孤立性肺结节诊断的循证分析[J].中国医学影像技术,2004,20(11):1754-1756. 被引量：14
  • 3钟秀君,周建英.葡萄糖转运蛋白与肺癌[J].国外医学（呼吸系统分册）,2005,25(2):118-120. 被引量：5
  • 4杨友,韩丹,赵川,金树珍,吕绍茂.血清PSA与前列腺癌病理分级的相关性[J].现代泌尿外科杂志,2006,11(4):200-202. 被引量：11
  • 5Chung JK, Lee YJ, Kim SK, et al. Comparison of [ 18F]fluorode- oxyglucose uptake with glucose transporter - 1 expression and proliferation rate in human glioma and non - small - cell lung cancer [J]. Nucl Med Commun,2004 ,25 ( 1 ) : 11 - 17.
  • 6de Geus - Oei LF, van Krieken JH, Allredjo RP, et al. Biological correlates of FDG uptake in non - small cell lung cancer [ J ]. Lung Cancer,2007,55 ( 1 ) :79 - 87.
  • 7Marom EM, Aloia TA, Moore MB, et al. Correlation of FDG - PET imaging with Glut - 1 and Glut - 3 expression in early - stage non- small cell lung cancer [ J ]. Lung Cancer,2001,33 (2- 3 ) : 99 - 107.
  • 8Mamede M, Higashi T, Kitaichi M, et al. [ ^18 F] FDG uptake and PCNA ,Glut- 1, and Hexokinasc-Ⅱ expressions in cancers and inflammatory lesions of the lung[ J ]. Neoplasia, 2005,7 ( 4 ) : 369 - 379.
  • 9Schwartzenberg- Bar- Yoseph F, Armoni M, Kamieli E,et al. The tumor suppressor p53 down - regulates glucose transporters Glut - 1 and Glut4 gene expression [J].2004, 64(7) :2627 -2633.
  • 10Sasaki M, Sugio K, Kuwabara Y, et al. Alterations of tumor suppressor genes (Rb, p16, p27 and p53 ) and an increased FDG uptake in lung cancer [J]. Ann Neucl Med,2003,17(3) :189 - 196.

引证文献3

二级引证文献6

国外医学（放射医学核医学分册）
2003年 第3期

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