摘要
目的 :观察连续给予补肾益骨膏对大鼠肝、肾的损害作用及其损害的可逆性。方法 :将 14 4只大鼠分成对照组 ,补肾益骨膏高、低剂量组 ,各组动物按 1.5mL·kg 1 等体积分别灌胃 ,高、低剂量组分别按 60 .0 ,15 .0g·kg 1 给予补肾益骨膏 ,对照组给予等体积的纯化水 ,每天连续灌服给药 ,周日休息 ,共 180d ;用药 90 ,180d及停药 3 0d ,分 3批处死动物 ,采血进行与肝、肾功能相关的血清生化检测及其病理组织学检查。结果 :补肾益骨膏长期给药对肾脏有可疑损害作用 ,对肝脏有轻度可逆性损害作用。结论 :临床长期大剂量使用补肾益骨膏应注意肝、肾功能的检查。
Objective:To evaluate the hepatic and renal damage of bushenyigugao in rats and the reversibility of these damage. Method:144 rats were divided randomly into three groups. 44 rats in control group received distilled water; 50 rats in high-dose group received 60.0 g·kg -1 intragastric administration per day; 50 rats received 15.0 g·kg -1 intragastric administration per day. After 90 day's , 180 day's administration and in the 30th day after 180 day's administration, the level of aspartate aminotransferase (AST), albumin aminotransferase (ALT), alkaline phophatase (ALP), blood urea nitrogen (BUN), creatinine (Cr) in the serum was detected, meanwhile liver and renal pathology was examinated by light microscopy. Results:Long-term bushenyigugao using may lead to renal damage and reversible low-grade liver damage. Conclusion:The hepatic and renal function tests should be performed periodly with long-term high-dose bushenyigugao using.
出处
《医药导报》
CAS
2003年第9期600-601,共2页
Herald of Medicine
基金
广东省科委基金资助项目 (基金编号 :SKF9810 )
