摘要
目的 :探讨高同型半胱氨酸血症(HHcy)与复发性脑梗死 (RCI)的关系 ,为缺血性脑血管病的二级预防开辟新的预防和治疗途径。方法:将80例急性脑梗死患者 ,分为首发性脑梗死组 (FCI组 )43例 ,复发性脑梗死组(RCI组 )37例 ,利用高效液相色谱法测定空腹血浆同型半胱氨酸(tHcy)水平 ,并与40例健康者(对照组)对照研究。结果 :⑴空腹血浆tHcy 水平RCI组为 (23.96±6.07) μmol/L ,FCI组为 (21.61±4.72) μmol/L ,两组比较差别有统计学意义 (P<0.05)。⑵FCI组中HHcy14例 ,发生率32.56 % ;RCI组中HHcy17例 ,发生率45.95% ,正常对照组HHcy40例 ,发生率5 %。RCI组HHcy 的检出率显著高于FCI组 ,且2者检出率均显著高于对照组(均P<0.05)。⑶空腹血浆tHcy水平与RCI具有显著相关性 ,而与高血压病、血脂异常、糖尿病、吸烟及饮酒等RCI可能的危险因素无显著相关性 ,提示HHcy 可能是RCI的一个独立的危险因素。结论 :HHcy与RCI关系密切 ,可能为其一个独立的危险因素。
Objective:To study the relationship between hyperhomocysteinemia(HHcy)and recurrent cereˉbral infarction(RCI).Methods:Eighty patients with acute cerebral infarction(ACI)were divided into a first crebral infarction(FCI)group(n=43)and a RCI group(n=37),and40healthy people acted as control group.Results:⑴The levels of plasma fasting homocysteine in the RCI group(23.96±6.07)μmol/L was sigˉnificantly higher than that in the FCI group(21.61±4.72)μmol/L(P<0.05).⑵The incidence of HHcy in the RCI group(17/37,45.95%)was significantly higher than that in the FCI group(14/43,32.56%),and both of them were higher than the incidence of HHcy in the control group(2/40,5%)(all P<0.05).Conclusion:HHcy may be an independently risk factor that is associated with RCI.
出处
《天津医药》
CAS
北大核心
2003年第7期411-413,共3页
Tianjin Medical Journal
基金
天津市自然基金资助项目(项目编号:00360411)
