期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

小儿病毒性脑炎脑脊液可溶性细胞粘附分子-1的变化及其意义 被引量：3

Dynamic changes of the soluble cellular adhesion mole-cules-Ⅰ in cerebrospinal fluid in children with the virus encephalitis
下载PDF
导出
摘要 为了探讨病毒性脑炎患儿脑脊液 (CSF)的可溶性细胞粘附分子 -1(sICAM -1)的变化及其临床意义 ,在进行脑脊液常规、生化检查的基础上 ,采用酶联免疫吸附试验对22例病毒性脑炎患儿在不同时期 (急性期、恢复期 )的脑脊液进行sICAM -1水平的测定 ,并进行分析对比。结果 :病毒性脑炎患儿急性期脑脊液的sICAM -1水平(4.16±1.97ng/ml)明显高于对照组(1.24±0.11ng/ml) ,P<0.001 ,且脑脊液WBC数与sICAM -1水平呈正相关 (r=0.842,P<0.001) ;sICAM -1水平与病情危重评分得分呈负相关 (r= -0.991,P<0.001)。恢复期脑脊液的sICAM -1水平(1.55±0.52ng/ml)明显低于急性期(4.16±1.98ng/ml) ,P<0.001 ,但与对照组(1.24±0.11ng/ml)比较差异无显著性 ,P>0.05。提示病情越重 ,脑脊液sICAM -1水平越高 ,随着病情的恢复 ,脑脊液sICAM -1水平含量逐渐降低 ;病毒性脑炎脑脊液的sICAM -1水平对判断疾病严重程度和预后具有重要的指导意义。
作者 林冬云 侯燕明 周伟
机构地区 暨南大学医学院第五附属医院 广东省广州市儿童医院新生儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2003年第7期414-415,共2页 Journal of Clinical Pediatrics
关键词 小儿 病毒性脑炎 脑脊液 可溶性细胞粘附分子-1 变化
分类号 R725.1 [医药卫生—儿科]
  • 相关文献

参考文献11

二级参考文献29

  • 1金伯泉.粘附分子[M].西安:世界图书出版公司,1995.63-64.
  • 2Ley K, Tedder TI Leukocyte interactions with vascular endothelium: New insights into selectimnediated attachment and rolling[J]. J Immunol, 1995,155(2):525 - 528.
  • 3Siemiatkowski A, Kosel J. Adhesion molecules and their role in organ response after trauma[J]. Pol Meruriusz Lek, 2001,10(60):465- 468.
  • 4Muller WA, Weigl SA, Deng X, et al. PECAM- 1 is required for transendothelial migration of leukocytes[J]. J Exp Med, 1993, 178(2): 449 - 460.
  • 5Zocchi MR, Ferrero E, Leone BE, et al. CD31/PECAM- 1 -driven chemokine- independent transmigration of human T lymphocytes[J]. Eur J Immunol, 1996,26(4):759- 767.
  • 6Del Ma.schio A. De Luigi A, Martin-Padura I, et al. Leukocyte recruitment in the oerebrospinal flid of mice with experimental lneningitis is inhibited by an antibody to junctional adhesion molecule (JAM)[J]. J Exp Med. 1999.190(9);1351 -1356.
  • 7Kniesel U, Wolburg H. Tight junctions of the bolld-brain barrier[J]. Cell Mol Neurobiol. 2000,20(1):57- 76.
  • 8Rieckmann P. Nunke K. Burchhardt M, et al. Soluble intercellular adhesion molecule- 1 in cerebrospinal fluid: an indicator for nflammatory impairment of the blood -cerebrospinal fluid barrier[J]. J Neuroimmunol. 1993,47(2):133- 140.
  • 9Tuomanen ET, Prasad SM. George JS, et al. Reversible opening of the blood -brain barrier by antibacterial antibodies[J]. Proc Natl Acad Sci USA, 1993,90(16):7824-7828.
  • 10Wang X, Yue TL. Barone FC, et al. Demonstration of increased endothelial - leukocyte adhesion molecule - 1 mRNA expression in rat ischemic cortex[J]. Stroke, 1995,26(9):1665 - 1669.

共引文献164

同被引文献30

  • 1赵瑞芹,孙素真,王晓明,杨花芳,赵敬肖,任军英.中枢神经系统感染患儿脑脊液中可溶性细胞间黏附分子-1及白介素-6的变化[J].中国实用儿科杂志,2005,20(2):110-112. 被引量：4
  • 2吴瑞萍 胡亚美.诸福棠实用儿科学（第6版）[M].北京:人民卫生出版社,1996.279.
  • 3MaisnerA, Neufeld J, Weingartl H. Organ-and endothel- iotropism of Nipah virus infections in vivo and in vitro [J]. Thromb Haemost,2009,102(6) : 1014-1123.
  • 4胡亚美,江载芳.诸福棠实用儿科学[J].7版.人民卫生出版社,2002:759-762.
  • 5Maximova OA, Faucette LJ, Ward JM, et al. Cellular inflammatory response to flaviviruses in the central nervous system of a primate host [J]. J Histochem Cytochem,2009, 57 (10) : 973 -989.
  • 6Hyun YM, Chung HL, McGrath JL, et ol. Activated integ- rin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1[J].J Immunol,2009,183 (1): 359-369.
  • 7Shrestha B, Zhang B, Purtha WE, et al. Tumor necrosis factor alpha protects against lethal West Nile virus infec- tion by promoting trafficking of mononuclear leukocytes into the central nervous system [J]. J Virol, 2008,82(18) : 8956-8964.
  • 8Bradford RD, Pettit AC, Wright PW, et al. Herpes simplex encephalitis during treatment with tumor necrosis factor- alpha inhibitors [ J ]. Clin Infect Dis, 2009,49 ( 6 ) : 924-927.
  • 9Iwasawa K, Kameyama T, Ishikawa H, et al. Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-alpha [J]. Acta Histochem Cytochem, 2008,41 (5) : 115-120.
  • 10Zapolska-Downar D, Namszewicz M. Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappa B (NF-kappa B) activation [J]. J Physiol Pharmacol,2009,60(2) : 123-131.

引证文献3

二级引证文献15

临床儿科杂志
2003年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部