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肿瘤基因治疗 被引量:2

Genetherapy for Cancer
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摘要 在单基因缺陷遗传病的基因治疗取得重要研究进展的同时,涉及多基因异常的肿瘤基因治疗研究也取得了令人瞩目的突破.从五个方面考虑肿瘤的基因治疗:信息药物法,导入反意核酸或核酸代酶信息药物抑制肿瘤恶性基因的表达;遗传免疫调节法,导入细胞因子基因刺激对肿瘤细胞毒的免疫反应;正常组织保护法,导入外源基因增强正常细胞对化疗和放疗的抗性,最大限度减小化疗和放疗对正常组织的损伤;药物打靶法,导入外源病毒特殊酶的基因,使这个基因选择性地在肿瘤细胞中表达,进而把一些低毒的原药转化为高毒药物,有针对性地杀伤肿瘤细胞;基因取代疗法,导入外源基因纠正抑癌基因的缺陷,恢复抑癌功能.
机构地区 军事医学科学院
出处 《科技导报》 CAS CSCD 1992年第8期28-30,共3页 Science & Technology Review
关键词 肿瘤 基因 治疗
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同被引文献17

  • 1Keiichi Mise,Norimichi Kan,Takashi Okino,Yoshio Moriguchi,Takehisa Harada,You Ichinose,Kazutomo Inoue. OK-432-combined adoptive immunotherapy as a prognostic factor in peritoneal metastasis from gastric cancer[J] 1994,Surgery Today(1):54~58
  • 2Toshihiro Fujimoto,Kazuhiko Omote,Masayoshi Mai,Shunnosuke Natsuume-Sakai. Evaluation of basic procedures for adoptive immunotherapy for gastric cancer[J] 1992,Biotherapy(2):153~163
  • 3Yoshinori Nio M.D.,Kazuhisa Ohgaki,Toshiharu Tsuchitani,Shiro Imai,Takahiro Shiraishi,Takayoshi Tobe. Orally administered streptococcal preparation, OK-432 augments the antitumor immunity of patients with gastric or colorectal cancer[J] 1990,Biotherapy(3):213~222
  • 4Masaaki Takeshita MD,Fujio Makita,Izumi Takeyoshi,Hitoshi Ishikawa,Seiji Nakamura,Susumu Owada,Yukio Miyamoto,Masaru Izuo,Satonori Kurashige. Anti-tumor effects of the oral administration of the streptococcal preparation OK-432 (PICIBANIL) — the inhibition of carcinogenesis and growth in rats with ENNG-induced gastrointestinal tumors[J] 1990,The Japanese Journal of Surgery(3):316~326
  • 5Tetsuya Toge MD,Hiroshi Kuninobu,Yoshiyuki Yamaguchi,Nobutoshi Baba,Yasuhide Kegoya,Takao Hattori. The clinical efficacy of intratumoral OK-432 administration in advanced cancer patients[J] 1988,The Japanese Journal of Surgery(6):668~674
  • 6Minoru Niimoto MD,Takao Hattori,Ryuichiro Tamada,Keizou Sugimachi,Kiyoshi Inokuchi,Nobuya Ogawa. Postoperative adjuvant immunochemotherapy with mitomycin C, futraful and PSK for gastric cancer. An analysis of data on 579 patients followed for five years[J] 1988,The Japanese Journal of Surgery(6):681~686
  • 7F. K. Stevenson.DNA vaccines against cancer: From genes to therapy[J].Annals of Oncology.1999(12)
  • 8Parkhurst MR,Salgaller ML,Southwood S, et al.Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp 100 modified at HLA-A0201-Binding residues[].J Immunol.1997
  • 9Laheru DA,Jaffee EM.Potential role of tumor vaccines in GI malignancies[].Oncolngy Hunting.2000
  • 10Boon T,Van Pel A,De Plaen E, et al.Genes coding for T-cell-defined tumor transplantation antigens: point mutations, antigenic peptides, and subgenic expression[].Cold Spring Harbor Symposia on Quantitative Biology.1989

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