期刊文献+

HGF-c-met信号转导与肿瘤侵袭和转移的关系 被引量:4

原文传递
导出
摘要 肝细胞生长因子 (HGF)是一种多功能细胞因子 ,HGF通过与c met受体结合激活受体酪氨酸蛋白激酶活性调节细胞的分裂、增殖、分化、迁移等。故HGF c met信号转导在肿瘤的侵袭转移中发挥重要作用。
作者 姜虹 吴焕明
出处 《国外医学(生理病理科学与临床分册)》 2003年第3期235-237,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
  • 相关文献

参考文献17

  • 1Zeng Q, Chen S, You Z, et al. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NF-кB [ J]. J Biol Chem, 2002,277(28): 25203-25208.
  • 2Hubbard SR, Mohammadi M, Schlessinger J. Autoregulatory mechanisms in protein-tyrosine kinases [ J ]. J Biol Chem, 1998,273(20) :11987-11990.
  • 3Bardelli A, Longati P, Williams TA, et al. A peptide representing the carboxyl-terminal tail of the met receptor inhibits kinase activity and invasive growth[ J]. J Biol Chem,1999,274(41 ):29274.
  • 4Recio JA and Merlino G. Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1 [J]. Oncogene, 2002,21(7):1000-1008.
  • 5Paumelle R, Tulasne D, Kherrouche Z, et al. Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway [ J ]. Oncogene, 2002,21(15) :2309-2319.
  • 6Nakajima M, Sawada H, Yamada Y, et al. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas [ J ]. Cancer, 1999,85 ( 9 ) : 1894 - 1902.
  • 7Chen BK, Ohtsuki Y, Furihata M, et al. Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage [ J]. Pathol Res Pract, 1999, 195(6) :427-433.
  • 8Ghoussoub RA, Dillon DA, D'Aquila T, et al. Expression of c-met is a strong independent prognostic factor in breast carcinoma [ J ].Cancer,1998,82 ( 8 ) 11513-1520.
  • 9Maehara N, Matsumoto K, Kuba K, et al. NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells[J]. Br J Cancer, 2001,84(6) :864-873.
  • 10Horikawa T, Sheen TS, Takeshita H, et al. Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma[J]. Am J Pathol, 2001,159( 1 ) :27-33.

同被引文献81

引证文献4

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部