摘要
目的探讨多药耐药蛋白P糖蛋白(Pgp)、拓扑异构酶-Ⅱ(Top-Ⅱ)以及表皮生长因子受体(EGFR)在结直肠癌中的表达及意义。方法使用免疫组织化学法检测我院2015-01-2015-12入院结直肠癌组织患者的Pgp、Top-Ⅱ以及EGFR蛋白表达,并分析同病理参数之间的关系。结果无远隔转移组的Top-Ⅱ表达率高于远隔转移组,差异有统计学意义,P<0.05;Pgp以及EGFR表达同患者的年龄、性别、肿瘤位置、TNM分期、浸润深度无相关性,P>0.05。结论无远隔转移患者Top-Ⅱ在结直肠癌组织当中的表达较高,传统化疗耐药以及敏感患者肿瘤组织当中均存在西妥昔单抗靶点。
OBJECTIVE To explore the multidrug resistance protein P-glycoprotein(Pgp),a topoisomerase Ⅱ(Top-Ⅱ)and Expression and significance of epidermal growth factor receptor(EGFR)in colorectal cancer.METHODS Pgp Top-Ⅱ and protein expression using immunohistochemistry in colorectal cancer tissue,EGFR,and to analyze the relationship between the parameters with pathology.RESULTS No Top-Ⅱexpression rate of distant metastasis to distant metastasis significant difference was statistically significant(P<0.05);Pgp and EGFR expression with age,sex,tumor location,TNM stage,depth of invasion was no significant relationship(P>0.05).CONCLUSION No distant metastases Top-Ⅱ were highly expressed in colorectal cancer tissues,among them,as well as resistant to conventional chemotherapy in patients with tumors sensitive to the presence of both cetuximab targets.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2016年第S2期41-42,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
多药耐药蛋白
拓扑异构酶
表皮生长因子受体
结直肠癌
表达
multidrug resistance protein
topoisomerase
epidermal growth factor receptor
of colorectal cancer
expression
