摘要
目的 :研究联合采用六味五灵片和熊去氧胆酸治疗失代偿期乙肝肝硬化的临床效果。方法 :将2011~2014年我院收治的78例失代偿期乙肝肝硬化患者作为研究对象,将其随机分为治疗组(n=38)和对照组(n=40)。为两组患者采用常规抗病毒及保肝疗法进行治疗,在此基础上为治疗组患者联合采用六味五灵片和熊去氧胆酸进行治疗,为对照组患者应用水飞蓟宾胶囊进行治疗,然后在用药12周后对比观察其临床表现、肝功能指标及Child-pugh评分的变化情况、治疗的总有效率及发生不良反应的情况。结果 :与对照组患者相比,治疗组患者在进行治疗后其肝功能指标、凝血酶原时间、Child-pugh的评分均较优,差异显著(P<0.05),有统计学意义。与对照组患者相比,治疗组患者治疗的总有效率较高,差异显著(P<0.05),有统计学意义。两组患者在进行治疗期间均未发生明显的不良反应。结论 :联合采用六味五灵片和熊去氧胆酸治疗失代偿期乙肝肝硬化可取得较好的临床效果,显著改善患者的肝功能,此法值得在临床上推广应用。
Objective: To investigate the clinical effect of Liuweiwuling tablets combined ursodeoxycholic acid On HBV-induced decompensated cirrhosis. Methods: 78 HBV-induced decompensated cirrhosis patien ts from 2011 to 2014 were randomly divided into treatment group (n=38) and control group (n=40). After the conventional liver protecting treatment, treatment group received Liuweiwuling tablets combined ursodeoxycholic acid, and control group received Silibinin Capsules for 12 weeks. To detect clinical symptom, liver f unction, the change of Child-P ugh grade, total effective rate, adverse reactions, etc. Treatm ent effect between these 2 groups was compared. Results: The levels of total effective rate, TBIL, TBA, ALT, AST, ALP, GGT, CHE, ALB, PT, Child-Pugh grade on treatment group was obviously higher than control group. Conclusion: Clinical effect of Liuweiwuling tablets combined ursodeoxycholic acid on HBV-induced decompensated cirrhosis was better.
关键词
熊去氧胆酸
六味五灵片
乙肝肝硬化
黄疸
疗效观察
ursodeoxycholic acid
Liuweiwuling tablets
jaundice
HBV-induced cirrhosis
clinical effect
