摘要
目的 探讨日间CRRT对急性呼吸窘迫综合症患者血浆炎症介质水平的影响。方法 应用日间CRRT对 12例急性呼吸窘迫综合征患者进行治疗 ,酶联免疫吸附分析方法检测治疗前和治疗后2、4、6、8、12和停止治疗后 12小时血浆中TNF -α、IL - 1β、6、8的浓度。结果 CRRT治疗 2小时后 ,血浆TNF -α、IL - 1β、6、8水平开始下降 ,至 6～ 8小时达到最低水平 ,P <0 .0 1,停止CRRT治疗后 12小时上述因子均有不同程度的回升 ,但仍低于治疗前水平。结论 CRRT对ARDS患者血浆中细胞因子的清除是确切和有效的 ,并且提示该种透析膜对炎症介质的清除方式以吸附为主。
Objective To investigate the effects of daytime continuous renal replacement therapy on the plasma level of inflammatory mediators in acute respiratory distress syndrome. Methods Daytime CRRT were used to treat the patients who suffered from ARDS and the TNF-α、IL-1β、6、8 plasma levels were measured by enzyme-linked immunoassay(ELISA)at 0,2,4,6,8,10,12 hour following CRRT and 12 hour post CRRT.Result TNF-α、IL-1β、6、8 plasma levels start to reduce at 2 hour and decreased to lowest levels at 6 hours following CRRT(P<0.001) and slightly elevated at 12 hours post CRRT but still lower than the levels before CRRT. Conclusion CRRT can effectively clearance these inflammatory mediators. The results suggest that the clearance of these mediators may mainly be due to absorption.
出处
《中国血液净化》
2003年第8期430-432,共3页
Chinese Journal of Blood Purification
