摘要
目的:探讨儿童先天性甲状腺功能异常与其智能发育的关系。方法:采用对照研究的方法,对出生时甲状腺素(TSH)介于5～20mU/L的2～4岁儿童(n=198)使用DDST进行筛查,同时设置正常儿童对照组(n=198,TSH≤5mU/L)进行对比研究,对筛查出的问题儿童,再次使用儿童神经心理发育量表进行测查,进一步明确先天性甲状腺功能异常与智能发育的关系。结果:①经DDST筛查,对照组儿童智能发育正常的比例为100%,实验组儿童智能发育正常的比例为93.9%,发育可疑的比例为4.0%,发育异常的比例为2.0%,经统计学检验,两组儿童筛查结果具有显著性差异(χ2=12.37,P<0.005)。②经儿童神经心理发育量表测试,本研究中儿童智能发育处于中等以下水平的比例为1.25%。③经多元逐步回归分析发现儿童TSH水平、早期教育因素、家庭经济状况、儿童营养状况、家庭重视程度为影响DDST筛查结果的主要因素。结论:儿童先天性甲状腺功能异常是影响儿童智能发育的重要相关因素。
AIM:To explore the relationship between the children with inherent thyroid gland dysfunction and their intellectual development. METHOD:DDST was used to screen 198 children aged 2- 4 years, 112 male and 86 female, with thyroid stimulating hormone(TSH) between 5 and 20 mU/L when born. Simultaneously, 198 age matched normal children from the same region, with TSH ≤ 5 mU/L, were used as controls. Problem children were measured again by Child Nerve Mental Development Scale to further verify the relationship between inherent thyroid gland dysfunction and intellectual development. RESULT:① DDST screening showed that the rate of normal development in the control group was 100% , while that of the experimental group was 93.9% . The rates of suspicious development and abnormal development were 4.0% and 2.0% in the experimental group respectively. There was a significant difference between the development of the two groups (χ 2=12.37, P< 0.005).② Child Nerve Mental Development Scale indicated that about 1.25% children's intelligence were below the normal level in this research.③ Multiply stepwise regression analysis showed that the TSH level, early education, economic status, nutritional status and family attention degree were the main factors to influence the screening of DDST.
出处
《中国临床康复》
CSCD
2003年第21期2960-2961,共2页
Chinese Journal of Clinical Rehabilitation
关键词
儿童
先天性甲状腺功能异常
智能发育
筛查
影响因素
营养状况
家庭重视程度
Inherent thyroid gland dysfunction is the important related factor that influences the intellectual development of children.
