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脂联素与动脉粥样硬化 被引量：6

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摘要 脂联素是新近发现的脂肪细胞特异性蛋白,研究显示脂联素与胰岛素抵抗关系密切,并且脂联素通过抑制内皮细胞粘附分子的表达、内皮细胞及平滑肌细胞的增殖、巨噬细胞向泡沫细胞转变、参与终止与动脉粥样硬化有关的炎症反应,以及改善脂肪代谢等发挥其抗动脉粥样硬化的作用。对脂联素在抗动脉粥样硬化方面的基础及临床研究,为防治糖尿病大血管并发症提供了一个新的思路。
作者 侯新国 陈丽
机构地区 山东大学齐鲁医院内分泌科
出处 《国外医学（内分泌学分册）》 2003年第4期256-258,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 脂联素 动脉粥样硬化 胰岛素抵抗 血管内皮细胞 血管平滑肌细胞 巨噬细胞 炎症反应
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献18

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  • 2Lindaay R S, Funahashi T, Hanson R L, et al. Adiponeetin and development of type 2 diabetes in the Pima Indian population [ J ]. Lancet, 2002,360 : 57-58.
  • 3Stefan N, Vozarova B, Funahashi T, et al. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans[J]. Diabetes ,2002,51 : 1884-1888.
  • 4Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein [ J ]. Diabetes, 2001,50 : 2094-2099.
  • 5Hirose H, Kawai T, Yamamoto Y,et al. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes[J]. Metabolism ,2002,51:314-317.
  • 6Combs T P, Wagner J A, Berger J, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists:a potential mechanism of insulin sensitization [ J ]. Endocrinology, 2002,143 : 998-1007.
  • 7Yang W S, Jeng C Y, Wu T J, et al. Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone,increases plasma levels of adiponectin in type 2 diabetic patients [ J ]. Diabetes Care, 2002,25 : 376-380.
  • 8Fasshauer M, Klein J, Neumann S, et al. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes [ J ]. FEBS Lett,2001,507 : 142-146.
  • 9Nishizawa H, Shimomura I, Kishida K, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipo-cyte-derived protein[ J ]. Diabetes, 2002,51 : 2734-2741.
  • 10Yamauehi T, Kamon J, Waki H, et al.The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity[J]. Nat Med,2001,7:941-946.

同被引文献68

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国外医学（内分泌学分册）
2003年 第4期

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