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新一代骨代谢生化标志物的临床应用 被引量：2

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摘要 按照骨代谢生化标志物(BMBM)临床应用价值和发现时间,可以将BMBM划分为经典的BMBM、新的BMBM和可反映骨代谢的其他新的生化标志物。经典的BMBM特异性及敏感性低,易受其他因素影响。而新一代BMBM特异性、敏感性高,受外界因素影响小,其中许多生化标志物如骨保护素、瘦素及胰岛素样生长因子等在骨偶联水平调节骨吸收和骨形成的动态平衡,在骨的生理重建和代谢性骨病机制中发挥重要作用,在临床上具有广泛的应用前景。
作者 单鹏飞 廖二元
机构地区 中南大学湘雅二医院代谢内分泌研究所
出处 《国外医学（内分泌学分册）》 2003年第4期259-262,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 骨代谢生化标志物 骨保护素 瘦素 胰岛素样生长因子
分类号 R446.1 [医药卫生—诊断学]
  • 相关文献

参考文献22

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同被引文献11

  • 1中华人民共和国卫生部.中药新药临床研究指导原则[S].第1辑.1993.
  • 2Thomas T,Burguera B,Melton L,et al.Role of serum leptin,insulin,and estrogen levels as potential mediators of the relationship betweem fat mass and bone mineral density in men versus women[J].Bone,2001,29:114-120.
  • 3Sato M,Takeda N,Sarui H,et al.Association between serum leptin concentrations and bone mineral density,and biochemical markers of bone turnover in adult men[J].J Clin Endocrinol Metab,2001,86:5273-5276.
  • 4Janne E R,Unni S.leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralitation.J Bone miner Res,2001,16(8):1426.
  • 5Yamanchi M,Sugimoto T,Yamaguchi T,et al.plasma leptin concentrations are associated with bone mincral density and zpresece of vertebral fratures in pestmonopasal women.Clin Endocrinal (oxf),2001,55(3),347.
  • 6Thomas T,Gori F,Khosta S,et al.Leptin acts on human marrow stromal cell to enhance differentiation to osteoblats and to inbibit differetiation to adipocytes.Endocrinlogy,1999,140(4):1630.
  • 7Lwamoto I,Douchi T,Kosha S,et al.Relationships between serum leptin level and regional bone mineral density,bone metabolic markes in healthy women.Acta Obstet Gynecol Scand,2000,79:1060-1064.
  • 8Blain H,vuillemin A,Cuillemin F,et al.Surum leptin level is a predictor of bone mineral density in postmenopausal women.J Clin Endocrinol Metab,2002,87:1030-1035.
  • 9李双庆,赵红莉,李晓佳,魏松全,安振梅,熊中云,谢秦.人成骨细胞瘦素受体放射配基结合分析研究[J].华西医科大学学报,2002,33(3):375-378. 被引量：6
  • 10谭正怀,沈映君.瘦素与骨质疏松[J].国外医学（内分泌学分册）,2002,22(4):231-233. 被引量：6

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国外医学（内分泌学分册）
2003年 第4期

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