摘要
目的 探讨抗RA33、抗CCP抗体对RA的诊断价值。方法 用ELISA方法分别检测 4 3例RA患者、2 3例非RA弥漫性结缔组织病患者、4 5例正常对照血清中抗RA33、抗CCP抗体水平。结果 抗RA33、抗CCP抗体对RA的诊断敏感性分别为 2 0 .9%、6 0 .5 % ,特异性分别为 88.2 %、97.1 %。结论 抗RA33抗体可作为RA的早期诊断指标 ,抗CCP抗体可以作为RA的特异性诊断指标。
Objective To explore the diagnostic value of anti RA33 antibody and anti cyclic citrullinated peptide antibody(anti CCP) in patients with rheumatoid arthritis.Methods The anti RA33 antibody and anti CCP antibody were detected by ELISA in 43 RA,23 rheumatic disease other than RA and 45 healthy individuals.Results The sensitivities of anti RA33 antibody and anti CCP antibody were 20.9%,60.5%;the specificities were 88.2%,97.1%,respectively.Conclusion Anti RA33 is helpful in the early diagnosis of RA.As a high specific diagnostic maker,anti CCP can improve the diagnostic sensitivity and specificity for RA when combined to detect IgM RF.
出处
《重庆医学》
CAS
CSCD
2003年第8期1033-1034,共2页
Chongqing medicine
