摘要
目的 探讨长期低铅染毒对大鼠内分泌脂质过氧化作用及超氧化歧化酶活性的影响。方法 将 4 0只大鼠随机分成 4组 ,分别给予含有不同剂量的铅饲料 8周 ,测定并分析大鼠染毒后血中、甲状腺、胰腺组织中的铅含量、MDA、T -SOD、CAT、GSH -Px含量 ,并进行相关分析。结果 各组血铅随染铅剂量升高而升高 ;甲状腺、胰腺组织中的MDA含量随染铅剂量升高而升高 ,并与血铅浓度呈正相关 ;而甲状腺、胰腺组织中的T -SOD和GSH -Px含量随染铅剂量升高而下降 ,并与血铅浓度呈负相关 ;甲状腺、胰腺组织中的CAT与染铅剂量无关。结论 慢性铅中毒增强机体的脂质过氧化作用 ,降低机体抗氧化酶系活力 ,可能参与了体内某些内分泌功能和组织学的损害机制。
Objective To observe effects of lipid peroxidation and superoxide dismutase of endocrine in rats chronically poisoned with low levels of lead. Methods Forty rats were randomly divided into four groups.They received lead diets of different levels for eight weeks.Serum level of lead MDA,T-SOD,CAT,GSH-Px in blood thyroid and pancreas are measured and analysed after the rats are poisoned. Results The levels of blood lead in all groups increased with the lead dose.The levels of MDA increased with the lead dose and were correlated positively with the levels of blood lead in the thyroid and pancreas.The levels of T-SOD and GSH-Px decreased with the lead dose and were correlated negatively with the levels of blood lead in the thyroid and pancreas.The levels of CAT had no correlation with the levels of blood lead in the thyroid. Conclusion The chronic lead poisoning increased the effect of lipid peroxidation and decreased the vitality of anti-oxidase,which may be a part of some endocrine functions and the harm mechanism of histology.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第8期1000-1001,共2页
Chinese Journal of Public Health
关键词
铅
大鼠
内分泌
脂质过氧化
lead
rat
endocrine
lipid peroxidation
