摘要
目的掌握深圳市耐利福平结核病中耐多药结核病检出情况及其分布特征,为制定耐药结核病临床治疗及预防控制措施提供理论依据。方法收集2016—2018年在中国疾病预防控制信息系统《结核病信息管理系统》登记报告的深圳市耐药可疑肺结核患者信息资料,对耐利福平肺结核及其中的耐多药肺结核病检出情况、分布特征进行分析。结果2016—2018年报告耐药可疑肺结核病7 669例,检出耐利福平肺结核病664例,检出率为8.7%。其中耐多药肺结核病506例(占76.2%);2016—2018年耐利福平肺结核病检出率分别为8.5%、9.1%、8.3%,差异无统计学意义(P>0.05);耐多药肺结核病检出率分别为6.3%、7.5%、6.0%,差异无统计学意义(P>0.05)。2016—2018年共报告耐利福平肺结核病男性检出率为8.7%,女性为8.6%,差异无统计学意义(P>0.05);耐多药肺结核病男性检出率为6.3%,女性为7.2%,差异无统计学意义(P>0.05)。职业分类为教师、学生、农民、民工、餐饮食品业的耐利福平结核病患者中耐多药结核病患者占100.0%,登记分类为返回的耐利福平结核病患者中耐多药结核病患者占100.0%。结论深圳市耐利福平肺结核病中耐多药结核病检出率较高,在师生、农民工及返回类耐利福平结核病患者中表现最为明显,建议对该类耐利福平结核病患者的治疗尽早采取强化方案,提高师生及农民工患者管治质量,避免服药中断,降低耐药肺结核病发生。
Objective To identify the detection and distribution characteristics of multidrug-resistant tuberculosis among rifampicin-resistant tuberculosis patients in Shenzhen.It provides a theoretical basis for the formulation of clinical treatment and prevention strategy for drug-resistant tuberculosis.Methods To collect the information material of registered drug-resistant suspected TB patients reported by China’s disease prevention and control information system from 2016 to 2018,and analyze the detection and distribution characteristics of multidrug-resistant TB among rifampicin-resistant TB patients by using Chi-square test to compare the difference in rates.Results Totally 7 669 cases of drug-resistant suspected TB were reported in Shenzhen from 2016 to 2018,664 cases were found to be rifampicin-resistant TB(The detection ratio was 8.7%),among them,506 cases were multidrug-resistant TB which accounted for 76.2%.From 2016 to 2018,the detection rates of rifampicin-resistant TB were 8.5%,9.1%and 8.3%,and there were no significant differences among them(P>0.05).The detection rates of multidrug-resistant TB were 6.3%,7.5%and 6.0%,and there were no significant differences among them either(P>0.05).There were 8.7%male and 8.6%female with rifampicin-resistant TB respectively,with no statistically significant differences(P>0.05).There were 6.3%male and 7.2%female with multidrug-resistant TB,and there were no significant differences(P>0.05).Multidrug-resistant TB patients in the occupational classification of teachers,students,farmers,migrant workers,food and beverage industry accounted for 100.0%of rifampicin-resistant TB patients.The returning multidrug-resistant patients also accounted for 100.0%.Conclusion There was a high detection rate of multidrug-resistant TB among rifampicin-resistant TB patients in Shenzhen.Teachers,students,migrant workers and returning patients were the most obvious ones.Therefore,it was recommended to use early intensified treatment on rifampicin-resistant TB patients,improve the management quality for teachers,students and migrant workers,avoid treatment interruptions,and eventually reduce the incidence of drug-resistant TB.
作者
卢春容
吴清芳
谭卫国
卓志鹏
季乐财
罗一婷
车晓玲
杨冰玲
余卫业
LU Chunrong;WU Qingfang;TAN Weiguo;ZHUO Zhipeng;JI Lecai;LUO Yiting;CHE Xiaoling;YANG Bingling;YU Weiye(Tuberculosis Department,Center for Chronic Disease of Shenzhen,Shenzhen,Guangdong 518020,China)
出处
《中国热带医学》
CAS
2019年第9期856-859,867,共5页
China Tropical Medicine
基金
深圳市科技创新计划基础研究项目(No.JCYJ20160428145728055)
深圳市卫计委科研项目(No.SZXJ2017035)
深圳市医疗卫生三名工程(No.SZSM201611030)
关键词
结核病
耐药性
耐多药性
利福平
耐多药结核病
检出率
Tuberculosis
resistant
multidrug-resistant
Rifampicin
multidrug-resistant tuberculosis
detection rate
