摘要
目的:观察生大黄联合常规西药治疗重症急性胰腺炎(SAP)的临床疗效。方法:将87例SAP患者随机分组为2组,对照组44例给予生长抑素联合奥曲肽常规西药治疗,观察组43例在对照组治疗的基础上加用生大黄治疗;观察比较2组用药后各时间点急性生理与慢性健康(APACHE-Ⅱ)评分情况,比较2组患者用药后症状体征以及实验室指标复常时间、并发症好转情况。结果:治疗1、2周后,观察组患者APACHE-Ⅱ评分均明显低于对照组,差异有统计学意义(P <0.05)。治疗后,观察组患者腹痛缓解及肠鸣音、体温、淀粉酶复常时间均短于对照组,差异有统计学意义(P <0.05)。观察组肾功能衰竭、胃肠功能衰竭、急性呼吸窘迫综合征等并发症好转时间均短于对照组,差异有统计学意义(P <0.05)。结论:生大黄联合常规西药治疗SAP较单纯西药治疗更快速有效,且能更好地改善患者胰腺功能。
Objective:To observe the clinical effect of Radix et Rhizoma Rhei combined with routine western medicine in treating severe acute pancreatitis(SAP).Methods:A total of 87 cases of patients with SAP were randomly divided into two groups.The control group(44 cases)was treated with routine western medicine of somatostatin combined with octreotide,and the observation group(43 cases)was additionally treated with Radix et Rhizoma Rhei based on the treatment of the control group.The scores of Acute Physiology and Chronic Health EvaluationⅡ(APACHE-Ⅱ)in the two groups at each time point after medication were observed and compared.The symptoms and signs,the recovery time of laboratory indexes and the improvement of the complications in the two groups after medication were compared.Results:After treatment for one and two weeks,the score of APACHE-Ⅱin the observation group was obviously lower than that in the control group,the difference being significant(P<0.05).After treatment,the remission time of abdominal pain as well as the recovery time of bowel sounds,body temperature and amylase in the observation group was all shorter than that in the control group,the difference being significant(P<0.05).The improvement time of complications such as kidney failure,gastrointestinal failure and acute respiratory distress syndrome in the observation group was all shorter than that in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Radix et Rhizoma Rhei combined with routine western medicine in the treatment of SAP is faster and more effective than western medicine alone,which can better improve the pancreatic function of patients.
作者
丁宪春
陈月年
贾圣喜
夏秋敏
DING Xianchun;CHEN Yuenian;JIA Shengxi;XIA Qiumin
出处
《新中医》
CAS
2019年第4期147-149,共3页
New Chinese Medicine
关键词
重症急性胰腺炎
中西医结合疗法
生长抑素
奥曲肽
生大黄
Severe acute pancreatitis
Integrated Chinese and western medicine therapy
Somatostatin
Octreotide
Radix et Rhizoma Rhei
