摘要
目的:观察大黄芪汤加减联合西药治疗糖尿病足(DF)的临床疗效。方法:将98例DF患者按随机数字表法分为对照组和治疗组各49例。对照组给予甲钴胺注射液与拜阿司匹林治疗,治疗组在对照组基础上加用大黄芪汤加减治疗。对比2组中医证候评分、踝肱指数(ABI)及血管生成素-2 (Ang-2)和血管内皮生长因子(VEGF)水平。结果:治疗后,2组5项中医证候评分均较治疗前减少(P <0.01);治疗组5项中医证候评分均低于对照组(P <0.01)。治疗后,2组ABI值均较治疗前增高(P <0.01);治疗组ABI值大于对照组(P <0.01)。总有效率治疗组87.76%,高于对照组的69.39%,差异有统计学意义(P <0.05)。治疗后,2组血清VEGF水平均较治疗前升高(P <0.01),Ang-2水平均较治疗前降低(P <0.01);治疗组血清VEGF水平高于对照组(P <0.01),Ang-2水平低于对照组(P <0.01)。结论:大黄芪汤加减联合西药治疗DF疗效显著,作用机制可能与调节VEGF和Ang-2水平有关。
Objective:To observe the clinical effect of modified Da Huangqi tang combined with western medicine for diabetic foot(DF).Methods:A total of 98 cases of DF patients were divided into the control group and the treatment group according to the random number table method,49 cases in each group.The control group was treated with mecobalamin injection and bayaspirin,and the treatment group was additionally treated with modified Da Huangqi tang based on the treatment of the control group.The Chinese medicine syndrome scores,the ankle-brachial index(ABI)as well as the levels of angiopoietin-2(Ang-2)and vascular endothelial growth factor(VEGF)in the two groups were compared.Results:After treatment,the five Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.01);the five Chinese medicine syndrome scores in the treatment group were lower than those in the control group(P<0.01).After treatment,the levels of ABI in the two groups were increased when compared with those before treatment(P<0.01);the level of ABI in the treatment group was higher than that in the control group(P<0.01).The total effective rate was 87.76%in the treatment group,higher than that of 69.39%in the control group,the difference being significant(P<0.05).After treatment,the levels of VEGF in serum in the two groups were increased when compared with those before treatment(P<0.01),and the levels of Ang-2 in the two groups were decreased when compared with those before treatment(P<0.01);the level of VEGF in serum in the treatment group was higher than that in the control group(P<0.01),and the level of Ang-2 in the treatment group was lower than that in the control group.Conclusion:The therapy of modified Da Huangqi tang combined with western medicine has significant curative effect in treating DF,whose mechanism is probably related to the regulation of the levels of VEGF and Ang-2.
作者
朱青燕
孙迪
ZHU Qingyan;SUN Di
出处
《新中医》
CAS
2019年第6期90-92,共3页
New Chinese Medicine
