摘要
目的:观察桂枝茯苓胶囊对子宫肌瘤患者血液流变学、性激素、孕激素受体(ER)、雌激素受体(PR)、血管内皮生长因子(VEGF)水平的影响。方法:将纳入观察的子宫肌瘤患者100例随机分为观察组与对照组各50例,2组患者均给与米非司酮口服治疗,观察组加服桂枝茯苓胶囊,均连续治疗3个月。观察治疗前后瘤体体积及子宫体积变化、血液流变学指标(血小板聚集率、全血黏度低切、血浆黏度、全血黏度高切)的变化、血性激素[雌二醇(E2)、孕酮(P)、睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)]变化,血清ER、PR、VEGF水平变化,评价其治疗疗效。结果:治疗后,2组瘤体体积及子宫体积均较治疗前缩小,且观察组小于对照组;2组血液流变学指标、E2、P、FSH、LH、ER、PR、VEGF均较治疗前下降,且观察组低于对照组,差异均有统计学意义(P <0.05);但T指标与治疗前后比较,差异无统计学意义(P> 0.05)。总有效率观察组94.0%,对照组76.0%,观察组高于对照组,差异有统计学意义(P <0.05)。结论:桂枝茯苓胶囊治疗子宫肌瘤有助于缩小瘤体及子宫体积,改善血液流变学,降低性激素及ER、PR、VEGF水平,从而提高疗效。
Objective:To observe the effect of Guizhi Fuling capsules on the levels of hemorheology,sex hormones,estrogen receptor(ER),progesterone receptor(PR)and vascular endothelial growth factor(VEGF)in patients with hysteromyoma.Methods:Divided 100 cases of patients with hysteromyoma into the observation group and the control group randomly,50 cases in each group.Both groups received the oral administration of mifepristone,while the observation group additionally received the oral administration of Guizhi Fuling capsules.The treatment of both groups lasted for 3 months continuously.Observed the changes in the size of tumor body,uterine volume,hemorheological indexes(platelet aggregation rate,low-shear whole blood viscosity,plasma viscosity,high-shear whole blood viscosity),blood sex hormones(E2,P,T,FSH,LH)and levels of serum ER,PR and VEGF in both groups before and after treatment,and evaluated the clinical effect.Results:After treatment,the size of tumor body and uterine volume in both groups were reduced when comparing with those before treatment,and each index above in the observation group was lower than that in the control group;the hemorheological indexes and the levels of E2,P,FSH,LH,ER,PR and VEGF in both groups were respectively lower than those before treatment,and each index above in the observation group was lower than that in the control group,differences being significant(P<0.05);comparing the level of T in both groups before and after treatment,there was no significant difference being found(P>0.05).The total effective rate was94.0%in the observation group and 76.0%in the control group,difference being significant(P<0.05).Conclusion:Guizhi Fuling capsules for hysteromyoma helps reduce the size of tumor body and uterine volume,improve hemorheology and decrease the levels of sex hormone,PR,ER and VEGF,thus to enhance the clinical effect.
作者
司玉红
朱景华
冀淑英
王慧霞
SI Yuhong;ZHU Jinghua;JI Shuying;WANG Huixia
出处
《新中医》
CAS
2019年第10期179-182,共4页
New Chinese Medicine
基金
河南省中医药科学研究专项项目(2015ZY02108)
关键词
子宫肌瘤
桂枝茯苓胶囊
血液流变学
性激素
孕激素受体
雌激素受体
血管内皮生长因子
Hysteromyoma
Guizhi Fuling capsules
Hemorheology
Sex hormone
Progesterone receptor
Estrogen receptor
Vascular endothelial growth factor
