摘要
目的对自制VB1 HBS(受试制剂 )和市售普通制剂 (参比制剂 )进行动物单剂量口服实验以比较其药动学特征。方法用荧光法测定VB1的血药浓度 ,运用 3 p87药动学程序进行了模拟。结果VB1 HBS和VB1普通片给药后 ,VB1 HBS的AUC、tmax、cmax 分别为 7 73 3h·(mg·L-1)、1 5 2 0h、1 0 44mg·L-1,VB1普通片AUC、tmax、cmax 分别为 3 663h·(mg·L-1)、0 895h、1 5 0 8mg·L-1。VB1 HBS相对生物利用度为 2 0 6 0 1 %。结论家兔体内VB1的药代动力学规律均符合血管外给药一级吸收二室模型。与参比制剂相比 ,受试制剂的AUC、tmax、cmax都较参比制剂高 ,VB1
Objective To compare the pharmacokinetics of VB 1-HBS and VB 1-Tab.Method VB 1-HBS and VB 1-Tab were administrated to rabbits by a single dose.The fluorescence method was used to determine the plasma concentration of VB 1.Pharmacokinetic parameters were calculated by the 3p87 pharmakinetics program. Result AUC,t max,c max of VB 1-HBS were 7 733 h·(mg·L -1),1 520 h, 1 044 mg·L -1, AUC,t max,c max of VB 1-Tab were 3 663 h·(mg·L -1),0 895 h, 1 508 mg·L -1.The bioavailability of VB 1-HBS was 206 01%.Conclusion The pharmacokinetics of VB 1 in rabbits accord with the two compartment models and with the 1 st absorption after VB 1-HBS or VB 1-Tab administration. AUC, c max, t max, and MRT of VB 1-HBS were all higher than those of VB 1-Tab, and VB 1-HBS had a higher bioavailability, which reached the object of this task.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第5期332-335,共4页
Journal of Shenyang Pharmaceutical University
