摘要
目的对比观察急性脑梗死患者血小板α颗粒功能变化 ,及口服不同剂量阿司匹林的临床效果。方法 6 7例急性脑梗死患者随机分为对照组 (n =2 2 )、试验 1组 (n =2 3)和试验 2组 (n =2 2 ) ,试验组入院后当天开始口服阿司匹林 ,试验 1组 1 5 0mg/d ,试验 2组 30 0mg/d ;对照组则口服安慰剂 ,连续 1 4d ,于治疗前、治疗后 3d、7d和 1 4d检测血浆血小板α颗粒膜蛋白 1 4 0 (GMP 1 4 0 )、β -血小板球蛋白 (β TG)和血小板因子 4 (PF4)。结果三组患者治疗前、治疗后 3d上述参数比较差异无显著意义 (P >0 .0 5 ) ;入院后 7d和 1 4d ,上述参数比较差异有显著意义 (P <0 .0 5或P <0 .0 1 ) ,且试验 2组明显低于试验 1组 (P <0 .0 5 )。结论急性脑梗死患者血小板处于激活状态 ,其释放功能增强 ,阿司匹林有减轻其释放的作用 。
Objective To evaluate the effects of orally low-dose aspirin therapy at acute cerebral infarct patients and investigate the function changes of platelet. Methods 67 cases with acute cerebral patients were divided into test group I, test group II and control group, The test group I was applied aspirin therapy (150mg/d) and the test group II was applied 300mg/d, placebo was applied in the control group, The blood plasma platelet granular membrane protein 140(GMP 140), β thromboglobulin(β TG) and platelet factor 4(PF4) were measured on different time. Results The changes of GMP 140, β TG and PF4 in three groups have no different before treat and 3 day after treat with aspirin, but there were significantly less in test groups than those in the control group ( P <0.05 or P <0.01) on 7 day, 14 day after treat with aspirin. Furthermore, there were significantly different between the test groups( P <0.05). Conclusion The function of platelet has a great change at acute cerebral infarct patients and take orally low-dose aspirin therapy has a better effect certainly.
出处
《贵州医药》
CAS
2003年第8期698-700,共3页
Guizhou Medical Journal
