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EMA/CO方案在滋养细胞肿瘤治疗中的评价 被引量:10

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摘要 放线菌D、足叶乙甙、甲氨蝶呤、长春新碱、环磷酰胺药物组成的联合化疗方案(EMA/CO方案)是目前治疗高危及耐药滋养细胞肿瘤疗效最肯定的方案,单独给药78.8%的患者得到完全缓解,综合治疗则缓解率达94.6%,5年生存率达86.2%,若对EMA/CO方案耐药及复发者应用足叶乙甙、顺铂/EMA(EP/EMA)方案解救仍有70%以上再次获得缓解和存活。该方案接受性好,无致死性毒反应发生,停药2~6个月后月经恢复。远期可引起绝经提前甚至卵巢功能早衰,轻度诱发白血病及乳腺癌等第二肿瘤的发生。
出处 《国外医学(妇产科学分册)》 CAS 2003年第4期225-228,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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