摘要
目的 探讨抑癌基因 PTEN蛋白在大肠癌的表达及临床意义。方法 免疫组化 S- P法检测 92例大肠癌组织中 PTEN蛋白的表达。结果 大肠癌组织和癌旁组织 PTEN蛋白阳性率分别为 6 7.39%和 6 6 .0 7% ,与正常大肠组织 PTEN表达的差异有显著性意义 (P<0 .0 1) ,与大肠癌的组织学分级正相关 ,与淋巴结转移、临床分期和生存率无明显相关。癌和癌旁组织的 PTEN蛋白表达呈现高度的同步性 (P<0 .0 1)。结论 提示 PTEN在大肠癌的发生发展中起着重要的作用 。
Objective To explore the expression and clinical significance of PTEN gene in large intestine carcinoma.Methods\ Immunohistochemical staining(SP plus)was used to determine the expression of PTEN in 92 cases of large intestine carcinoma.Results\ The positive incidences of PTEN expression in large intestine carcinoma and adjacent to large intestine carcinoma were 67 39% and 66 07%,It had significant correlation to the difference of PTEN expression in normal large intestine tissue( P <0 01),The expression of PTEN was correlated to histology grading,but not to lymphaden metastasis、 clinical stage and survival rate.There was significant correlation between carcinoma and adjacent to carcinoma( P <0 01) Conclusion\ It is suggested that PTEN plays important role in the appearance and development of large intestine carcinoma.Negative of PTEN may be a signal of appearance of large intestine carcinoma.
出处
《福建医药杂志》
CAS
2003年第4期1-2,共2页
Fujian Medical Journal
