摘要
救脱Ⅰ号注射液对麻醉开胸兔BP有快速提升作用,1g/kg·iv与辛弗林相近,强于多巴胺(P<0.01)。并对心脏有显著地兴奋作用,表现为增加心肌收缩力(dp/dtmax和Vce-cicp),其效应均强于辛弗林和多巴胺(P<0.01)。增强心泵血功能,CI和SI二项指标均优于辛弗林和多巴胺(P<0.01),LVWI略强于辛弗林但显著强于多巴胺(P<0.01);而TTI则明显低于辛弗林(P<0.01)但高于多巴胺(P<0.05)。因此救脱Ⅰ号的心脏效率(TTI/LVWI)匀显著高于辛弗林和多巴胺。救脱Ⅰ号对TPR的作用影响不大,略强于多巴胺(P<0.05)但显著小于辛弗林(P<0.01)。表明救脱Ⅰ号具有强心,升压,提高心脏效率等功能,其综合效应优于一般常用的抗休克心血管活性药物。
In this experiment by 22 anesthetized open-chest rabbits, it was discovered that the'injectio JIOUTOU'(IJT) had effects of rapidly raising BP, increasing the dp/dt max and Vce-cicp, and strengthening the CI, SI and LVWI. There were signifieant differences as compared with Dopamine(DA)and Neosyephrine(Nph). Since TTI's increment of IJT was markedly lower than NPh (P<0.01) and slightly higher than DA (P>0.05), the efficiency of heart (TTI/LVWI) was higher than DA and NPh (P all<0.01). IJT increased TDR slightly and had no significant difference as compared with DA (P>0.05), but had one with NPh which increased TPR rapidly (P<0.01). The results of study show that IJT, a new drug of CTM, excels the general cardiovascular active mdicine of anti- shock.
