摘要
目的:评价端粒长度与泌尿系统肿瘤发生风险之间的关系。方法:检索2017年3月前发表于PubMed, Medline以及中国知网等数据库中关于评价端粒长度与泌尿系统肿瘤发生风险之间关系的文献,以OR及95%CI评价两者间的风险关系。结果:通过文献阅读和筛查,共纳入10篇相关文献,经Meta分析后证实:与正常端粒长度人群相比,端粒长度缩短并不增加泌尿系统肿瘤的发生风险,OR及95%CI为1.10 (0.90, 1.36)。结论:本研究结果显示端粒长度缩短并不增加泌尿系统常见恶性肿瘤的总体发生风险,但依旧需要大样本前瞻性研究验证。
Objectives: Estimate the association between shortened telomeres and urinary system cancer risk. Methods: PubMed, Medline select the studies ed-effects or random-effects model, urinary system cancer for the shortest vs. the longest length of telomere was 1.10(0.90, 1.36). Conclusions: Our study suggests that there was a no significant association between shortened telomeres and urinary system cancer risk. However, more well-design prospective studies and more studies based on other populations are warranted.
出处
《中国妇幼健康研究》
2017年第S4期450-451,共2页
Chinese Journal of Woman and Child Health Research
关键词
端粒
膀胱癌
肾癌
前列腺癌
META分析
Telomeres
bladder cancer
prostate cancer
renal cancer
meta-analysis
