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缬沙坦与依那普利、氨氯地平治疗高血压疗效比较 被引量:4

Comparison on Effects of Vasartan and Enalapril,Amlodipine Treating Patients with Hypertension
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摘要 目的 与依那普利及氨氯地平相比较评价缬沙坦治疗原发性高血压病的疗效及安全性。方法 采用随机双盲试验 ,将 2 3 5例轻、中度高血压病患者随机分为缬沙坦组 (n =82 )、依那普利组 (n =76)和氨氯地平组 (n =77)。分别服用缬沙坦 80mg/d、依那普利 10mg/d或氨氯地平 5mg/d ,共 8周。用药 4周后对舒张压≥ 90mmHg者 ,以上剂量加倍。 结果  8周末缬沙坦、依那普利和氨氯地平均能有效降压 ,有效率分别为 63 .4%、65 .8%、64 .9% ;组间差异无统计学意义。三者降压幅度无显著性差异 (P >0 .0 5 )。依那普利组干咳发生率达 14 .5 % (11/ 76) ,缬沙坦组干咳发生率为 1.2 % (1/82 ) ,二者相比差异有显著性 (P <0 .0 1) ,氨氯地平组出现面部潮红 3 .9% (3 / 77) ,踝肿 2 .6% (2 / 77) ,与前两组相比有显著性差异 (P <0 .0 1)。结论 缬沙坦治疗轻、中度高血压病疗效确切 ,可逆转患者心肌重塑 。 Objective To evaluate the antihypertension efficacy and safety of valsartan compared with enalapril and amlodipine.Method 235 patients with mild or moderate hypertension were divided randomizedly into three groups and received valsartan 80mg/d(n=82),enalapril 10mg/d(n=76) or amlodipine 5mg/d(n=77) respectively for 8 weeks.The dosage would be doubled in patients whose diastolic pressure was ≥90mmHg after 4 weeks.Results Valsartan,enalapril and amlodipine could control blood pressure effectively.The effective rates did not differ significantly among the three groups(63.4% vs 65.8% vs 64.9%) at the end of 8 weeks.There were no significant differences in the decreased range of blood pressure among three groups( P >0.05).The occurrent rate of dry cough was 14.5%(11/76) in enalapril group and 1.2%(1/82) in valsartan group.There was a significant difference between two groups( P <0.01).Face flushing[3.9%(3/77)] and ankle swelling[2.6%(2/77)] were found in amlodipine group,which were significantly different compared with other two groups( P <0.01).Conclusions Valsatan is effective and well tolerated in patients with mild or moderate hypertension.
出处 《现代诊断与治疗》 CAS 2003年第5期272-273,共2页 Modern Diagnosis and Treatment
关键词 缬沙坦 依那普利 氨氯地平 治疗 高血压 疗效比较 Hypertension Valsartan Enalapril Amlodipine
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  • 1Colussi DM, Parisot C, Rossolino ML, et al. Protein binding plasma of valsartan, a new angiotensin II receptor antagonist[J ]. J Clin Pharmacol, 1997, 37:214.
  • 2Holwerda NJ, Fogaari R, Angeli P, et al. Valsaartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril[J]. J Hypertens, 1996, 14: 1147-1151.
  • 3Corea L, Cardoni O, Fogari R, et al. Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension a comparative study of the efficacy and safety against amlodipine[J ]. Clin Pharrncol Ther, 1996, 60.341.
  • 4Markham A, Goa KL. Valsartan a review of its pharmacology and the rapeutic use in essential hypertension[J ]. Drugs, 1997, 54: 299-311.
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