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地佐辛用于腹部全麻手术后的镇痛效果评价 被引量:18

Analgesic effect evaluation of dezocine in postoperative analgesia in abdominal surgery
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摘要 目的探讨地佐辛在腹部全麻手术术后镇痛效果。方法 80例(ASAⅠ~Ⅱ级)全麻腹部手术要求术后镇痛的患者,按术后镇痛药物不同随机均分为2组(n=40):地佐辛组(D组)地佐辛0.6 mg/kg+昂丹司琼4mg加0.9%氯化钠至100 mL,负荷剂量经静脉患者自控镇痛(intravenous patient-controlled analgesia,PCIA);芬太尼组(F组)芬太尼12μg/kg+昂丹司琼4mg加0.9%氯化钠至100 mL,负荷剂量加PCIA,记录术后2、4、8、12、24、48 h的视觉模拟评分(visual analog scale,VAS)及Ramsay镇静评分。结果 2组VAS评分及Ramsay评分差异无统计学意义,而不良反应发生率芬太尼组显著高于地佐辛组(P<0.01)。结论地佐辛组可为腹部全麻手术后患者提供较安全和舒适的镇痛作用。 Objective To investigate analgesia of dezocine in abdominal anesthesia postoperative.Methods 80 cases (ASA I ~II)abdominal surgery under general anesthesia patients required postoperative analgesia,according to different postoperative analgesia drug,patients were randomly divided into 2 groups:dezocine group (group D),dezocine 0.6 mg/kg+ondansetron 4mg plus 0.9% sodium chloride to 100 mL,loading dose of intravenous patient controlled analgesia (PCIA);fentanyl group (group F),fentanyl 12 g/kg+ondansetron 4mg plus 0.9% sodium chloride to 100 mL,loading dose plus PCIA,recorded after 2,4,8,12,24,48 h visual analog scale (VAS)and Ramsay sedation score.Results The 2 groups were not statistically significant differences in VAS score and Ramsay score,and the incidence of adverse reaction of fentanyl group was significantly higher than that of dezocine group (P<0.01).Conclusion Dezocine group could provide analgesia safe and comfortable for patients after abdominal operation under general anesthesia.
作者 李楠 王平英
出处 《中国生化药物杂志》 CAS 北大核心 2014年第7期156-157,共2页 Chinese Journal of Biochemical Pharmaceutics
基金 邯郸市科技局(1323108090-2)
关键词 地佐辛 芬太尼 术后镇痛 腹部手术 dezocine fentanyl postoperative analgesia abdominal surgery
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