摘要
目的分析并探讨厄贝沙坦联合苯磺酸氨氯地平对老年糖尿病高血压合并高尿酸血症患者的临床疗效。方法选取来北京积水潭医院接受治疗的糖尿病高血压合并高尿酸血症老年患者140例。随机分为观察组与对照组,每组70例。2组患者均给予常规降糖治疗,控制好患者血糖。在此基础上,观察组给予厄贝沙坦联合苯磺酸氨氯地平进行治疗,对照组仅给予厄贝沙坦进行治疗。结果 2组患者治疗后收缩压和舒张压与治疗前相比均有显著改善(P<0.05),观察组改善较对照组更加显著(P<0.05);2组患者治疗后血尿酸水平均有所下降(P<0.05),但2组间比较差异无统计学意义。观察组治疗有效率为92.85%,显著高于对照组的78.57%(P<0.05);观察组不良反应发生率为14.29%;对照组不良反应发生率为11.43%,2组差异无统计学意义。结论厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病高血压合并高尿酸血症临床效果显著,不良反应少。
Objective To analyze and discuss the clinical efficacy of irbesartan combined with amlodipine besylate in elderly diabetic patients with hypertension and hyperuricemia. Methods 140 elderly diabetes patients with hypertension and hyperuricemia admitted in Beijing Jishuitan Hospital were randomly divided into observation group and control group,70 cases in each group. All patients were treated with conventional hypoglycemic therapy to control blood sugar. On this basis,the observation group patients were given irbesartan combined with amlodipine besylate treatment; the control group were only given irbesartan treatment. Results After treatment,systolic and diastolic blood pressure of patients in two groups were significantly improved(P < 0. 05),and observation group improved more significantly compared with before treatment(P < 0. 05). After treatment,serum uric acid level in two groups were declined(P < 0. 05),but the difference between two groups was not statistically significant. The effective rate of observation group was92. 85%,higher than 78. 57% of control group. Adverse reaction rate of observation group was 14. 29%,and control group was 11. 43%,there was no significant difference between them. Conclusion Irbesartan combined with amlodipine besylate could achieve significant clinical effects and cause less adverse reactions in treatment with elderly diabetic patients with hypertension and hyperuricemia.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第8期157-158,161,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
教育部博士点基金项目(20090001120039)
