摘要
缝隙连接蛋白(Connexin,Cx)能够形成缝隙连接通道进行细胞间通讯,这是细胞之间直接进行信息交换的重要通道。而对于缝隙连接蛋白本身,在细胞的生长、分化、凋亡甚至肿瘤的形成和发展过程中也有着重要的调节作用。缝隙连接蛋白在多种肿瘤发展的不同阶段会出现表达水平的差异,并能与体内多种和细胞周期或肿瘤形成相关的蛋白发生相互作用,其自身也涉及多种调节与被调节机制。本文主要从缝隙连接蛋白与肿瘤形成和发展的关系,缝隙连接蛋白的基本作用机制以及其在抗肿瘤药物筛选及肿瘤治疗应用等方面进行论述。
Connexin( Cx) is the main component of gap junction channels,which is essential for intercellular communication between adjacent cells. Cx plays an important role in regulation of the growth,differentiation and apoptosis of cells and is closely related to tumor formation and development. The expression of Cx appears to be different in different stages of tumor development,and the regulatory mechanism of Cx is also involved in many aspects. In this paper,recent advances in the studies on Cx are reviewed,including the relationship between Cx and development of tumor,the basic mechanism of Cx,as well as its applications in antitumor-drug screening and tumor therapy.
出处
《中国生化药物杂志》
CAS
2015年第10期1-4,共4页
Chinese Journal of Biochemical Pharmaceutics
