摘要
目的比较炙甘草汤与真武汤对老年慢性心衰患者血流动力学、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)及心肌酶谱的影响差异。方法选取石河子大学医学院第一附属医院收治的老年慢性心衰患者40例,随机分为炙甘草汤组(n=20)与真武汤组(n=20)。2组患者均给予常规治疗,在常规治疗基础上按照不同分组给予相应药物治疗,治疗2周为1个疗程,共治疗2个疗程。治疗结束后,比较2组患者的血流动力学、MMP-9、TIMP-1及心肌酶谱指标。结果经治疗,2组患者血流动力学均改善,炙甘草汤组血流动力学各项指标改善优于真武汤组(P<0.05)。炙甘草汤组血清MMP-9及MMP-9/TIMP-1较真武汤组降低(P<0.05),炙甘草汤组血清TIMP-1较真武汤组增高(P<0.05)。治疗后2组心肌酶指标均降低,炙甘草汤各指标较真武汤组显著降低(P<0.05)。结论炙甘草汤能够明显改善老年慢性心力衰竭症状,疗效优于真武汤,对临床具有指导意义。
Objective To compare the effect of Zhigancao Decoction and Zhenwu Decoction on hemodynamics, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and myocardial enzyme of elderly patients with chronic heart failure.Methods 40 elderly patients with chronic heart failure in the first affiliated hospital of the medical college, Shihezi university were selected and randomly divided into Zhigancao Decoction group (n=20) and Zhenwu Decoction group (n =20) .The both of two groups were given conventional treatment, then were treated with respective drug according to different groups with two courses, one course of two weeks.The hemodynamic, MMP-9, TIMP-1 and myocardial enzyme spectrum indexes of two groups were compared post-treatment.Results After treatment, the indexes of hemodynamics in two groups were improved, hemodynamic indexes of Zhigancao Decoction recovered better than those of Zhenwu Decoction (P<0.05) .The serum MMP-9, MMP-9/TIMP-1 of Zhigancao Decoction group were lower and TIMP-1 was higher than those of Zhenwu Decoction group (P<0.05).The myocardial enzyme indexes in both groups were lower post-treatment, and the above indexes in Zhigancao Decoction were lower than those in Zhenwu Decoction group (P<0.05) . Conclusion Zhigancao Decoction could obviously improve the symptoms of chronic heart failure in elderly patients, which has the guiding significant in the clinical treatment.
出处
《中国生化药物杂志》
CAS
2015年第10期61-64,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
慢性心衰
炙甘草汤
真武汤
老年
基质金属蛋白酶-9
基质金属蛋白酶抑制剂-1
心肌酶
chronic heart failure
Zhenwu Decoction
Zhigancao Decoction
aged patients
matrix metalloproteinase-9
tissue inhibitor of metalloproteinase-1
myocardial enzymes
