摘要
本文报告80例甲状腺机能亢进症(甲亢)患者及80名正常健康人所测得的尿羟脯氨酸的排出量。结果表明甲亢患者尿羟脯氨酸的排出量显著高于对照组,经统计学处理有极显著差异(P<0.001)。甲亢患者经抗甲状腺药物治疗后,尿羟脯氨酸排出量逐步降低,至治疗后6个月,其排出量恢复正常,与对照组相比,P>0.05。尿羟脯氨酸排出量与T_3,T_4呈明显相关性。以上结果表明,尿羟脯氨酸测定可作为甲亢的诊断和疗效考核指标之一。
Urine hydroxyproline excretion was determined in 80 patients with hyperthyroidism and in a same number of healthy people as control. The results showed that urinary hydroxyproline contents in the patients with hyperthyroidism were obviously higher than that in the control, the difference between the two groups was statistically significant (P<0.001). After using tapazol, the urinary hydroxyproline contents were gradually lowered and reached normal after a 6-month treatment, the difference between the two groups was insignificant by then (P>0.05). Moreover, the urinary contents of hydroxyproline were found to be well correlated with the levels of T_3 and T_4. The results show that the urinary hydroxyproline determination could be used as an alternate index in the diagnosis of hyperthyroidism and to evaluate the effect of antithyroid drug therapy.
出处
《上海医学》
CAS
1988年第1期11-13,共3页
Shanghai Medical Journal
