摘要
目的观察胸腺肽联合阿苯达唑和/或吡喹酮两联驱虫药物治疗2例顽固多发性脑囊尾蚴病患者的疗效及预后。方法分析2例顽固多发性脑囊尾蚴患者的临床资料,动态追踪观察患者的疗效。结果单用及合用两种驱虫药物并延长疗程治疗效果不佳。检测免疫球蛋白IgM、IgA、IgG,淋巴细胞CD3+、CD4+、CD4+/CD8+、NK均低于正常范围,加用胸腺肽免疫增强治疗3个月后上述指标升高,影像学示颅内病灶明显减少,患者症状消失。结论免疫功能低下是顽固多发性脑囊尾蚴病驱虫治疗应答不佳的重要原因,加用免疫增强药物可提高患者体液免疫及细胞免疫功能,提高驱虫治疗效果。
Objective To observe the efficacy and prognosis of thymopeptide combined with albendazole and/or praziquantel in the treatment of 2 patients with persistent multiple cysticercosis.Methods The clinical data of 2 patients with persistent multiple cysticercosis were analyzed and the efficacy of patients was observed by dynamic tracking.Results One or two de-worming drugs and prolonged courses of treatment are not effective.The level of immunoglobulin IgM,IgA,IgG,lymphocytes CD3+,CD4+,CD4+/CD8+and NK in the 2 patients before treatment were below the normal range.The above indexes were increased after the addition of orally administered thymopeptide or intramuscular injection to regulate immunity after three months.Imaging examination showed intracranial lesions decreased significantly,and symptoms disappeared.Conclusion Hypoimmunity is an important reason for the poor efficacy of expelling worms for persistent and multiple cerebral cysticercosis.Adding immune system enhancing drugs can improve the humoral immunity and cellular immunity function of patients and improve the efficacy of de-worming therapy.
作者
李宏
汪娅
隋建美
谢静
LI Hong;WANG Ya;SUI Jianmei;XIE Jing(Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China)
出处
《寄生虫病与感染性疾病》
CAS
2019年第3期177-180,共4页
Parasitoses and Infectious Diseases
关键词
胸腺肽
免疫增强
脑囊尾蚴病
吡喹酮
阿苯达唑
thymopeptide
immunotherapy
cerebral cysticercosis
Praziquentel
Albendazole
