摘要
目的:探究针灸联合血府逐瘀胶囊治疗血栓闭塞性脉管炎(TAO)的临床疗效。方法:选取2017年3月至2018年4月盘锦市中心医院收治的TAO患者95例作为研究对象,按照随机数字表法随机分为对照组(n=47)和观察组(n=48)。对照组给予西医治疗,观察组在对照组的基础上给予针灸联合血府逐瘀胶囊治疗,2组均连续治疗6周。统计2组治疗后临床疗效,比较2组患者治疗前后中医证候积分,检测2组治疗前后血清ET-1、NO、hs-CRP水平,观察,2组治疗前后最大行走距离及ABI值。结果:治疗后观察组临床总有效率为91. 67%,显著高于对照组的65. 96%(P <0. 01);与治疗前比较,治疗后2组肢体疼痛、肢体麻木、肢体发凉、间歇性跛行、肢端皮色积分显著降低(P <0. 05或P <0. 01),且观察组显著低于对照组(P <0. 01);与治疗前比较,治疗后2组血清ET-1、hs-CRP水平显著降低(P <0. 01),血清NO水平显著升高(P <0. 05),且2组间比较差异有统计学意义(P <0. 01);与治疗前比较,治疗后2组ABI及观察组的最大行走距离显著升高(P <0. 01),且观察组均显著高于对照组(P <0. 01)。结论:针灸联合血府逐瘀胶囊可有效缓解TAO患者症状,抑制炎性反应,改善血管内皮细胞功能,提高下肢功能,且疗效显著优于西医治疗。
Objective: To explore the clinical efficacy of acupuncture combined with Xuefu Zhuyu Capsule in the treatment of patients with thromboangitis obliterans( TAO). Methods: A total of 95 cases TAO patients admitted to Panjin Central Hospital from March 2017 to April 2018 were selected and randomly divided into the control group( n = 47) and observation group( n = 48) according to random number table methods. The control group was treated with western medicine treatment,while the observation group was treated with acupuncture and Xuefu Zhuyu Capsule treatment on the basis of the control group. The 2 groups were treated for 6 weeks continuously. The clinical curative effects in the 2 groups were calculated after treatment;the traditional Chinese medicine( TCM) syndrome scores in the 2 groups were compared before and after treatment;the serum ET-1,NO and hs-CRP levels in the 2 groups were detected before and after treatment;the maximum walking distance and ABI value in the 2 groups were observed before and after treatment. Results: The clinical total effective rate in the observation group after treatment was 91. 67%,which was significantly higher than 65. 96% of the control group( P < 0. 01);compared with scores before treatment,the limb pain,limb numbness,limb cooling,intermittent claudication,limb end skin color scores in the 2 groups significantly decreased after treatment( P < 0. 05 or P < 0. 01),and the observation group was significantly lower than that of the control group( P < 0. 01);compared with levels before treatment,the serum ET-1 and hs-CRP levels in the 2 groups significantly decreased after treatment( P < 0. 01),the serum NO levels significantly increased( P < 0. 05),and there was a significant difference between the 2 groups( P < 0. 01);compared with values before treatment,the ABI value in the 2 groups and maximum walking distance in the observation group increased significantly after treatment( P < 0. 01). The observation group was significantly higher than that of the control group( P < 0. 01). Conclusion: Acupuncture combined with Xuefu Zhuyu Capsule can effectively alleviate the symptoms of TAO patients,inhibit the inflammatory reaction as well as improve the vascular endothelial cells function and lower limbs function. Its efficacy is superior to western medicine treatment.
作者
唐永
罗晓云
黄松
Tang Yong;Luo Xiaoyun;Huang Song(Department of Rehabilitation Medicine,Panjin Central Hospital,Panjin 124000,China;Mathematical Engineering Institute Affiliated to Guangzhou University of Chinese Medicine,Dongguan 523808,China)
出处
《世界中医药》
CAS
2019年第3期736-739,744,共5页
World Chinese Medicine
基金
广东省省级科技计划项目(2013A022100002)
关键词
血栓闭塞性脉管炎
针灸
血府逐瘀胶囊
疗效
炎性反应
下肢功能
Thromboangiitis obliterans
Acupuncture
Xuefu Zhuyu Capsule
Efficacy
Inflammatory reaction
Lower limbs function
